Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs405509
rs405509
APOE
0.020 GeneticVariation BEFREE APOE Variant (rs405509) might Modulate the Effect of Sex and Educational Level on Cognitive Impairment Risk in a Taiwanese Population. 31100889

2019
dbSNP: rs405509
rs405509
APOE
0.020 GeneticVariation BEFREE Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume? 27259692

2016
dbSNP: rs429358
rs429358
APOE
0.010 GeneticVariation BEFREE Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients. 31505070

2019
dbSNP: rs769449
rs769449
APOE
0.010 GeneticVariation BEFREE We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not. 24468470

2014
dbSNP: rs267606663
rs267606663
APOE
0.010 GeneticVariation BEFREE Dispersed association effects involving MutYH(His324Gln), MutYH(Met22Val), PolB(Pro242Arg) and NEIL2(Arg257Leu) were also detected when APOE or CHRNA4, were included in the statistical model, a result consistent with proposed involvement of the latter markers in human cognitive decline and/or function. 21884718

2011