|
rs72613567
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A common loss-of-function variant in HSD17B13 (rs72613567:TA) was recently found to protect from chronic liver disease.
|
31155741 |
2020 |
|
rs72613567
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A recent study identified a common SNP in HSD17B13 (rs72613567) that conferred protection from chronic liver disease.
|
31517326 |
2019 |
|
rs72613567
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A total of 3,315 European patients with HCC (n = 1,109) or without HCC, but with chronic liver disease (CLD; n = 2,206), from four centers were analyzed either by whole-exome sequencing (WES; exploratory cohort, 285 HCC) or genotyped for HSD17B13 rs72613567 (validation cohort, 824 HCC and all CLD).
|
30908678 |
2019 |
|
rs738409
|
|
|
0.030 |
GeneticVariation |
BEFREE |
High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease.
|
29578593 |
2018 |
|
rs738409
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The PNPLA3 I148M substitution is a major common genetic determinant of hepatic fat content and progression to chronic liver disease.
|
26355465 |
2016 |
|
rs738409
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results indicate that the PNPLA3 I148M variant is relevant for the retinyl-palmitate content in human liver, providing a possible link to chronic liver disease.
|
26439088 |
2015 |
|
rs58542926
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggested that TM6SF2 rs58542926 could be used to identify individuals at higher susceptibility to chronic liver disease, especially for HCC, cirrhosis, ALD, and NAFLD.
|
31309745 |
2019 |
|
rs58542926
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNPs in genes linked to HCC (DEPDC5, GRIK1, KIF1B, STAT4, MICA, DLC1, DDX18) or to liver damage (PNPLA3-rs738409, TM6SF2-rs58542926) in GWAS were genotyped in discovery cohorts including 1,020 HCC, 2,021 controls with chronic liver disease and 2,484 healthy individuals and replication was performed in prospective cohorts of cirrhotic patients with alcoholic liver disease (ALD, n = 249) and hepatitis C (n = 268).
|
30289982 |
2019 |
|
rs12979860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease.
|
25740255 |
2015 |
|
rs12979860
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL28B rs12979860 gene polymorphism in Egyptian patients with chronic liver disease infected with HCV.
|
25227816 |
2014 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, these findings support a larger scale screening for HERPUD1 R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.
|
28617828 |
2017 |
|
rs699947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Difference of polymorphism VEGF-gene rs699947 in Indonesian chronic liver disease population.
|
28837651 |
2017 |
|
rs7959378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that rs7959378 is associated with the risk of HCC in patient with chronic liver disease and prognosis of HCC patients after liver transplantation.
|
28348581 |
2017 |
|
rs11127
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HLA-DQ (rs9275572) and GNLY (rs1866139 and rs11127) were genotyped in 310 subjects with HBV-related chronic liver disease, 295 in whom spontaneous clearance of HBV had occurred and 316 who had not been exposed to HBV.
|
25644528 |
2015 |
|
rs1866139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HLA-DQ (rs9275572) and GNLY (rs1866139 and rs11127) were genotyped in 310 subjects with HBV-related chronic liver disease, 295 in whom spontaneous clearance of HBV had occurred and 316 who had not been exposed to HBV.
|
25644528 |
2015 |
|
rs9275572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HLA-DQ (rs9275572) and GNLY (rs1866139 and rs11127) were genotyped in 310 subjects with HBV-related chronic liver disease, 295 in whom spontaneous clearance of HBV had occurred and 316 who had not been exposed to HBV.
|
25644528 |
2015 |
|
rs2148356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TLR4 rs2148356 T allele is associated with a reduced risk of HCC and could slow down its clinical progression in HCV-induced chronic liver disease.
|
22286521 |
2012 |
|
rs28934571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasma R249S-mutated DNA was detectable at low concentrations (≥ 67 copies/mL) in 53 to 64% of patients with primary liver cancer or chronic liver disease and in 19% of controls.
|
22675488 |
2012 |
|
rs1800730
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India.
|
17589946 |
2007 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Absence of hemochromatosis associated Cys282Tyr HFE gene mutation and low frequency of hemochromatosis phenotype in nonalcoholic chronic liver disease patients in India.
|
14675248 |
2004 |