|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis.
|
25572736 |
2015 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TLR4 (Asp299Gly), TLR4 (Thr399Ile), and JUN (c.750G/A) SNPs showed no significant association with RSV disease.
|
21837802 |
2011 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
|
20711470 |
2010 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim was to study the association between the TLR4 Asp299Gly polymorphism and the susceptibility to severe RSV bronchiolitis in infants.
|
20575099 |
2010 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
By genotyping 236 children with RSV infection and 219 healthy controls we found no association between the risk of severe RSV infection and Asp299Gly polymorphisms (P>0.05), and we demonstrate that the TLR4 Asp299Gly genotype does not influence susceptibility to either RSV serotype A or B (P>0.05).
|
17449325 |
2007 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Both SNPs were highly associated with symptomatic RSV disease in this largely premature population (p < 0.0001), with 89.5% and 87.6% of cases being heterozygous for Asp299Gly and Thr399Ile polymorphisms versus published control frequencies of 10.5% and 6.5%, respectively.
|
17709532 |
2007 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The presence of TLR4 mutations (Asp299Gly and Thr399Ile) were associated with severe RSV bronchiolitis and were significantly over-represented in groups II and III.
|
16542364 |
2006 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls.
|
17264400 |
2006 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I).
|
15143473 |
2004 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis.
|
25572736 |
2015 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The TLR4 (Asp299Gly), TLR4 (Thr399Ile), and JUN (c.750G/A) SNPs showed no significant association with RSV disease.
|
21837802 |
2011 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
|
20711470 |
2010 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Both SNPs were highly associated with symptomatic RSV disease in this largely premature population (p < 0.0001), with 89.5% and 87.6% of cases being heterozygous for Asp299Gly and Thr399Ile polymorphisms versus published control frequencies of 10.5% and 6.5%, respectively.
|
17709532 |
2007 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The presence of TLR4 mutations (Asp299Gly and Thr399Ile) were associated with severe RSV bronchiolitis and were significantly over-represented in groups II and III.
|
16542364 |
2006 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls.
|
17264400 |
2006 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I).
|
15143473 |
2004 |
|
rs757275190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that infection of polarized Calu3 respiratory cells with recombinant RSV having point mutations in Cys173 and 176 (C173/176S) (rA2-GC12), or Cys186 (C186S) (rA2-GC4) is associated with a decline in the integrity of polarized Calu-3 cultures and decreased virus production.
|
28671606 |
2017 |
|
rs1800888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888), which was also nominally associated with asthma (p = 0.027) and active asthma (p = 0.013) among European Americans with severe RSV bronchiolitis without including the ESP.
|
26587832 |
2015 |
|
rs3138557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether IFN-γ CA microsatellite (rs3138557) polymorphism was associated with susceptibility to RSV in Chinese Han children and with the severity of the infection.
|
25130433 |
2014 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We assessed the relationship between polymorphisms rs7041 and rs4588, which define haplotypes GC1s, GC1f, and GC2, and RSV bronchiolitis susceptibility and subsequent asthma.
|
24447085 |
2014 |
|
rs7041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7041_C allele was also more frequent in the RSV bronchiolitis group compared with controls (OR 1.12, 95% CI 1.02, 1.4, P = 0.03) in the Netherlands, especially in mechanically ventilated patients (P = 0.009).
|
24447085 |
2014 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our human study, the A118G single nucleotide polymorphism rs1799971 was associated with respiratory syncytial virus disease severity (p = 0.015).
|
23222260 |
2013 |
|
rs4543123
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TLR1 variant (rs4543123) was associated with both multiple viruses (respiratory syncytial virus and parainfluenza virus) and multiple phenotypes.
|
23063165 |
2012 |
|
rs1799962
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of two SNPs in the IL-9 gene (rs2069885 and rs1799962) showed overrepresentation of the TT haplotype in girls with severe RSV bronchiolitis requiring hospitalization indicating that this is the haplotype conferring the highest risk in girls.
|
20503287 |
2010 |
|
rs2069885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of two SNPs in the IL-9 gene (rs2069</span>885 and rs1799962) showed overrepresentation of the TT haplotype in girls with severe RSV bronchiolitis requiring hospitalization indicating that this is the haplotype conferring the highest risk in girls.
|
20503287 |
2010 |