Gene: AMACR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10941112
rs10941112
AMACR ; C1QTNF3-AMACR
0.050 GeneticVariation BEFREE The current meta- analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. 25773837

2015
dbSNP: rs10941112
rs10941112
AMACR ; C1QTNF3-AMACR
0.050 GeneticVariation BEFREE Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer (P value = 0.047). 24383053

2013
dbSNP: rs10941112
rs10941112
AMACR ; C1QTNF3-AMACR
0.050 GeneticVariation BEFREE Significant evidence for association with prostate cancer risk for both the M9V and D175G variants was observed in the Tasmanian prostate cancer dataset. 18537123

2008
dbSNP: rs10941112
rs10941112
AMACR ; C1QTNF3-AMACR
0.050 GeneticVariation BEFREE Overall, prostate cancer was not related to AMACR gene variants; however, risks for prostate cancer were significantly reduced among regular ibuprofen users who carried allele variants at four nsSNP loci (M9V, D175G, S201L, and K277E; all P(trend) < 0.05) or carried the TGTGCG haplotype (OR = 0.65; 95% CI 0.44-0.97). 17680641

2007
dbSNP: rs10941112
rs10941112
AMACR ; C1QTNF3-AMACR
0.050 GeneticVariation BEFREE Furthermore, the AMACR sequence variants strongly cosegregate with CaP in HPC families (log of odds = 3.78; P = 0.00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008). 12438241

2002
dbSNP: rs2278008
rs2278008
AMACR ; C1QTNF3-AMACR
0.030 GeneticVariation BEFREE However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer. 25773837

2015
dbSNP: rs2278008
rs2278008
AMACR ; C1QTNF3-AMACR
0.030 GeneticVariation BEFREE AG or GG genotype of rs2278008 (E277K) tended to lower prostate cancer risk. 24383053

2013
dbSNP: rs2278008
rs2278008
AMACR ; C1QTNF3-AMACR
0.030 GeneticVariation BEFREE Overall, prostate cancer was not related to AMACR gene variants; however, risks for prostate cancer were significantly reduced among regular ibuprofen users who carried allele variants at four nsSNP loci (M9V, D175G, S201L, and K277E; all P(trend) < 0.05) or carried the TGTGCG haplotype (OR = 0.65; 95% CI 0.44-0.97). 17680641

2007
dbSNP: rs2287939
rs2287939
AMACR ; C1QTNF3-AMACR
0.020 GeneticVariation BEFREE The S201L polymorphism might also be linked with prostate cancer risk to some extent. 25773837

2015
dbSNP: rs3195676
rs3195676
AMACR ; C1QTNF3-AMACR
0.020 GeneticVariation BEFREE Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer (P value = 0.047). 24383053

2013
dbSNP: rs2287939
rs2287939
AMACR ; C1QTNF3-AMACR
0.020 GeneticVariation BEFREE Carriers of the variant T allele (rs2287939) had an OR of 0.81 (95% CI 0.68-0.97) for less aggressive PCa, but no alteration in risk for more aggressive PCa. 20945498

2011
dbSNP: rs3195676
rs3195676
AMACR ; C1QTNF3-AMACR
0.020 GeneticVariation BEFREE The strongest evidence for prostate cancer association was for SNP rs3195676, with an estimated odds ratio of 0.58 (95% confidence interval = 0.38-0.90; P = 0.01 for a recessive model). 17683075

2007
dbSNP: rs34677
rs34677
AMACR ; C1QTNF3-AMACR
0.010 GeneticVariation BEFREE However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer. 25773837

2015