|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We examined polymorphisms within ELAC2 (S217L, A541T, E622V), MSR1 (P275A, R293X, aIVS5-59c), and RNASEL (E265X, R462Q, D541E) in 150 European-Americans with metastatic prostate cancer and 170 prostate cancer-free controls using pyrosequencing assays.
|
16114055 |
2006 |
|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Of note, carriers of R293X were equally frequent in 367 sporadic prostate cancer cases (1.9%) and in 197 controls (2.0%).
|
16287155 |
2006 |
|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Several variants were significantly or marginally significantly associated with sporadic, not hereditary PCa risk, including R293X in white men (random effect OR = 1.34, P = 0.09) and D174Y in black men (random effect OR = 2.41, P = 0.04).
|
16425212 |
2006 |
|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Meta-analyses revealed significant associations of prostate cancer with MSR1 IVS7delTTA, -14,742 A>G, and Arg293X in European Americans; Asp174Tyr in African Americans; RNASEL Arg462Gln in European American's overall and in family history-negative disease; and Glu265X in family history-positive European Americans.
|
15824169 |
2005 |
|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
|
15734964 |
2005 |
|
rs41341748
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our results suggest that mutations in MSR1 gene might play a role in prostate cancer susceptibility, particularly the R293X mutation.
|
15042613 |
2004 |
|
rs2229388
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Based on our meta-analysis, the P275A polymorphism in the MSR1 gene is unlikely to be a risk factor for PCa.
|
26225686 |
2015 |
|
rs2229388
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The haplotype frequencies were significantly different between localized prostate cancer cases and controls, with a global P value of 0.004, and the haplotype containing the minor alleles of the P275A and INDEL7 variants was associated with a significantly reduced risk of localized prostate cancer (odds ratio = 0.28, 95% CI 0.13-0.59), relative to the most common haplotype.
|
17768178 |
2007 |
|
rs2229388
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Of the eight variants that affect the encoded protein (splice site, nonsense, and missense), only R293X as well as the polymorphism c.823C>G (P275A) were additionally present at remarkable frequencies in further samples of sporadic prostate cancer and controls.
|
16287155 |
2006 |
|
rs72552387
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Several variants were significantly or marginally significantly associated with sporadic, not hereditary PCa risk, including R293X in white men (random effect OR = 1.34, P = 0.09) and D174Y in black men (random effect OR = 2.41, P = 0.04).
|
16425212 |
2006 |
|
rs72552387
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Meta-analyses revealed significant associations of prostate cancer with MSR1 IVS7delTTA, -14,742 A>G, and Arg293X in European Americans; Asp174Tyr in African Americans; RNASEL Arg462Gln in European American's overall and in family history-negative disease; and Glu265X in family history-positive European Americans.
|
15824169 |
2005 |
|
rs72552387
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14).
|
12839931 |
2003 |
|
rs3747531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles of rs2243250 (T) in IL4 (OR = 1.46, 95% CI 1.03-2.08, P-trend = 0.03), rs1800896 (G) in IL10 (OR = 0.77, 95% CI 0.61-0.96, P-trend = 0.02), rs2430561 (A) in IFNG (OR = 1.33, 95% CI 1.02-1.74; P-trend = 0.04), rs3747531 (C) in MSR1 (OR = 0.55, 95% CI 0.32-0.95; P-trend = 0.03), and possibly rs4073 (A) in IL8 (OR = 0.81, 95% CI 0.64-1.01, P-trend = 0.06) were associated with higher- (Gleason 7-10; N = 222), but not lower- (Gleason 2-6; N = 380) grade prostate cancer.
|
28317149 |
2017 |
|
rs2127565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa.
|
26251261 |
2015 |
|
rs369108477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our large-scale analysis of case and controls from several countries found no evidence that the 999C>T mutation is associated with increased risk of prostate cancer.
|
15734964 |
2005 |