|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Three of the 14 SNPs were significantly associated with paediatric NAFLD after FDR adjustment, rs738409 (PNPLA3, P = 2.80 × 10<sup>-06</sup> ), rs1044498 (ENPP1, P = 0.0091) and rs780094 (GCKR, P = 0.0281).
|
30444569 |
2019 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Collectively, both our case-control study and meta-analysis confirm a significant association between rs780094 and NAFLD.
|
30646922 |
2019 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored.
|
29595690 |
2018 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Because PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants are known to confer susceptibility to NAFLD, we assessed the influence of MBOAT7 rs641738 on hepatic steatosis, and serum levels of CK-18 fragment (a biomarker of hepatocellular injury and apoptosis for NAFLD) after adjusting the effects of PNPLA3, GCKR and TM6SF2 polymorphisms.
|
29314568 |
2018 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Our meta-analysis provides evidence of significant association between GCKR rs780094 and risk of NAFLD.
|
25167786 |
2015 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
By studying the genetic variants of obese Taiwanese children, we confirmed that the genetic variants in GCKR rs780094 and PNPLA3 rs738409, but not in NCAN rs2228603, LYPLAL1 rs12137855, and PPP1R3B rs4240624, are associated with an increased risk of NAFLD.
|
24477042 |
2014 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
GCKR rs780094 was also associated with an increased ratio of visceral to subcutaneous fat area in the patients with nonalcoholic fatty liver disease.
|
24785259 |
2014 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs780094
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people.
|
20625834 |
2011 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Additionally, our results suggest Asian-specific, liver biopsy-specific, adult-specific and pediatric-specific associations between the rs1260326 and NAFLD.
|
30646922 |
2019 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD.
|
31255630 |
2019 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our results show that GCKR rs1260326 T-allele is associated with better response of NAFLD patients to nutritional treatment regarding fasting blood glucose, but not oxLDL levels.
|
28695325 |
2018 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Among individual variants, rs1260326 in GCKR and rs641738 in MBOAT7 (recessive), rs58542926 in TM6SF2 and rs738409 in PNPLA3 (dominant) emerged as associated to NAFLD, with PNPLA3 rs738409 being the strongest predictor (OR 3.12, 95% CI, 1.8-5.5, P < 0.001).
|
29487372 |
2018 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
|
rs1260326
|
|
|
0.760 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |