|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs6</span>41738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound <i>O</i>-acyltransferase domain-containing 7 (<i>MBOAT7</i>) and transmembrane channel-like 4 (<i>TMC4</i>) that associate with increased risk of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-related cirrhosis, and liver fibrosis in those infected with viral hepatitis (Buch et al., 2015; Mancina et al., 2016; Luukkonen et al., 2016; Thabet et al., 2016; Viitasalo et al., 2016; Krawczyk et al., 2017; Thabet et al., 2017).
|
31621579 |
2019 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CC genotype of TM6SF2 rs58542926 was associated with a significantly lower risk of NAFLD, while MBOAT7 rs641738 was not related to NAFLD risks.
|
30824369 |
2019 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We first demonstrated in childhood obesity the role of the MBOAT7 rs641738 variant on serum ALT and the combined effect of the MBOAT7, PNPLA3, and TM6SF2 variants on NAFLD risk.
|
29601441 |
2018 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the role of rs641738 in the pathogenesis of NAFLD is inconclusive.
|
29572551 |
2018 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 and rs58542926 variants, but not rs641738, were associated not only with non-alcoholic steatohepatitis (NASH) (odds ratio [OR], 2.00; 95% confidence interval [CI], 1.46-2.73 and OR, 1.91; 95% CI, 1.04-3.51) but also with significant fibrosis (≥ F2) (OR, 1.53; 95% CI, 1.11-2.11 and OR, 1.88; 95% CI, 1.02-3.46) in NAFLD, even after adjustment for metabolic risk factors.
|
29193269 |
2018 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants are known to confer susceptibility to NAFLD, we assessed the influence of MBOAT7 rs641738 on hepatic steatosis, and serum levels of CK-18 fragment (a biomarker of hepatocellular injury and apoptosis for NAFLD) after adjusting the effects of PNPLA3, GCKR and TM6SF2 polymorphisms.
|
29314568 |
2018 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interestingly, rs61756425 in PPP1R3B and rs641738 in MBOAT7 genes were predictors of NAFLD severity.
|
29487372 |
2018 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study.
|
27836992 |
2017 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
|
28674415 |
2017 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults.
|
27411039 |
2016 |
|
rs641738
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We provide evidence for an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent.
|
26850495 |
2016 |
|
rs1420472625
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In non-obese NAFLD patients, the frequency of the PNPLA3 p.I148M allele (74.6%), but not of the TM6SF2 or MBOAT7 polymorphisms, was significantly (P < 0.05) higher as compared to the other patients in the NAFLD CSG cohort (54.9%) or controls (40.2%).
|
29483677 |
2018 |
|
rs1420472625
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Notably, the I148M PNPLA3 variant has been identified as the major common genetic determinant of NAFLD.
|
29122391 |
2018 |
|
rs1420472625
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD).
|
27836992 |
2017 |
|
rs1420472625
|
|
|
0.040 |
GeneticVariation |
BEFREE |
NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants.
|
27576208 |
2016 |
|
rs626283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs626283 variant in the MBOAT7 gene is associated with NAFLD and may affect glucose metabolism by modulating intra-hepatic fat content in Caucasian obese children and adolescents.
|
29485130 |
2018 |