|
rs121912891
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, it is proposed that individuals who carry this c.3508G>A mutation in the COL2A1 gene should receive genetic counseling and early intervention for ANFH.
|
29750297 |
2018 |
|
rs121912891
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A new type II collagenopathy, caused by the p.Gly1170Ser mutation of COL2A1, which presents as premature hip osteoarthritis (OA), avascular necrosis of the femoral head (ANFH) or Legg-Calvé-Perthes (LCP) disease, was recently found in several families with an inherited disease of the hip joint.
|
20204389 |
2010 |
|
rs3219175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol-induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol-induced ONFH.
|
31207150 |
2019 |
|
rs34861192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol-induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol-induced ONFH.
|
31207150 |
2019 |
|
rs3745369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol-induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol-induced ONFH.
|
31207150 |
2019 |
|
rs7408174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol-induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol-induced ONFH.
|
31207150 |
2019 |
|
rs2274755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusting for age and gender, the logistic regression results showed that rs2274755 associated with a lower risk of non-traumatic ONFH in the dominant (OR=0.71, 95% CI: 0.54-0.94, p=0.016), overdominant (OR=0.73, 95% CI: 0.55-0.96, p=0.026) and log-additive (OR=0.74740; 95% CI, 0.578-0.949; p=0.017) models.
|
29137306 |
2017 |
|
rs1042034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age.
|
26617857 |
2015 |
|
rs632153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified rs632153 in ApoA1 gene was associated with increased risk of alcohol-induced ONFH using allele model (OR, 1.83; 95% CI, 1.16-2.88; P = 0.008) and log-additive model (adjusted OR, 1.77; 95% CI, 1.00-3.14; P = 0.046), analysis respectively.
|
26617857 |
2015 |
|
rs673548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age.
|
26617857 |
2015 |
|
rs676210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age.
|
26617857 |
2015 |
|
rs1193507525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our research, we identify a heterozygous mutation (c.1888 G>A, p. Gly630Ser) in exon 29 of COL2A1 in the Gly-X-Y domain, in a Chinese family affected by LCPD and ANFH.
|
24949742 |
2014 |
|
rs121912892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our research, we identify a heterozygous mutation (c.1888 G>A, p. Gly630Ser) in exon 29 of COL2A1 in the Gly-X-Y domain, in a Chinese family affected by LCPD and ANFH.
|
24949742 |
2014 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated the association of the 27-bp repeat polymorphism in intron 4 and G894T polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene with the pathogenesis of avascular necrosis of femoral head (ANFH).
|
24498338 |
2014 |
|
rs3135506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, respectively.
|
25515090 |
2014 |
|
rs662799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, respectively.
|
25515090 |
2014 |
|
rs2267439
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of rs2267439 TT and rs2267443 GA of SREBP2 and rs2453839 TT and CT of IGFBP-3 in the ANFH group showed increased and decreased tendencies (against normal control group), respectively.
|
23158139 |
2012 |
|
rs2267443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of rs2267439 TT and rs2267443 GA of SREBP2 and rs2453839 TT and CT of IGFBP-3 in the ANFH group showed increased and decreased tendencies (against normal control group), respectively.
|
23158139 |
2012 |
|
rs2453839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant finding was that the CT + CC genotype carriers of IGFBP-3 rs2453839 were highly associated with the development of ANFH.
|
23158139 |
2012 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients.
|
18214345 |
2007 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients.
|
18214345 |
2007 |