Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.050 | GeneticVariation | BEFREE | Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease. | 30288696 | 2019 |
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0.050 | GeneticVariation | BEFREE | We found that a substantial link exists between C677T polymorphism and LOAD risk in a codominant framework (TC vs. CC: OR=1.22, 95%CI=1.00-1.49, P=0.049). | 30631824 | 2019 |
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0.050 | GeneticVariation | BEFREE | The present results suggest that the MTHFR C677T polymorphism is likely a LOAD risk factor in our cohort, either in APOEɛ4 or in non-APOEɛ4 carriers. | 28211809 | 2017 |
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0.050 | GeneticVariation | BEFREE | We screened 378 late-onset Alzheimer's disease (LOAD) patients and 308 matched controls for the presence of the common MTHFR 677C>T, MTRR 66A>G, MTR 2756 A>G, and TYMS 28 bp repeat polymorphisms, searching for association with disease risk and age at onset. | 22034983 | 2012 |
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0.050 | GeneticVariation | BEFREE | Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. | 16055944 | 2005 |
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0.010 | GeneticVariation | BEFREE | APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD. | 31102717 | 2019 |
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0.010 | GeneticVariation | BEFREE | A functional polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer's disease (LOAD). | 28211809 | 2017 |