In the subgroup analysis by ethnicity, the results also showed no significant association between MTHFR C677T poly</span>morphism and susceptibility to osteoporotic fracture in postmenopausal women in both Caucasian and Asian populations.
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.