|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PNPLA3 I148M is associated with increased risk of prediabetes, metabolic syndrome and insulin resistance in obese patients with NAFLD.
|
31826069 |
2019 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD).
|
31851849 |
2019 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease.
|
30189691 |
2018 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Such potential examples of genotypes that are associated with a dissociation between liver disease and metabolic syndrome are patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) genotypes.
|
26978356 |
2016 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I148M variant in PNPLA3 and the E167K variant in TM6SF2 are both associated with increased liver fat content, but not features of the metabolic/insulin resistance syndrome.
|
27432073 |
2016 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 polymorphism is associated already in youths with increased ALT, and is more frequent in obese with MetS of all ages.
|
25939720 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD.
|
25624712 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Modern noninvasive liver graft assessment frequently detects hepatic steatosis, which is associated with graft fibrosis, components of the metabolic syndrome and recipient PNPLA3 rs738409 genotype, especially in ALC patients.
|
25429378 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G allele in PNPLA3 rs738409 increases the risk of NAFLD in the general population, especially in subjects without metabolic syndrome, independent of dietary pattern and metabolic factors.
|
24417250 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Age and HOMA-IR were positive independent predictors of metabolic syndrome, while a negative independent association was found between metabolic syndrome and the homozygotes PNPLA3 I148M variant.
|
24947770 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Inter99, we analyzed associations of rs738409 with components of the WHO-defined metabolic syndrome (n = 5,847) and traits related to metabolic disease (n = 5,663).
|
22792295 |
2012 |