|
rs2629540
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence.
|
29715653 |
2018 |
|
rs2629540
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs2629540
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs111325002
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs111325002
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs150954431
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs150954431
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs2005290
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs2005290
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs12071360
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
|
23958962 |
2014 |
|
rs6454674
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study confirms the association between rs6454674 and CD.
|
21790903 |
2013 |
|
rs16969968
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We replicated several previous findings, including associations between rs16969968 and nicotine dependence (P=0.002) and cocaine dependence (P=0.02), with opposite risk alleles for each substance.
|
20485328 |
2010 |
|
rs6454674
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The interaction between two independent CNR1 variants, ie, the G allele-containing genotypes of rs6454674 (SNP3(G+)), and the T/T genotype of rs806368 (SNP8(T)/T), significantly increased risk for CD in the EA family (P(GEE)=0.015) and EA case-control (P(regression)=0.003) samples.
|
19052543 |
2009 |
|
rs16969968
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor (A) allele of rs16969968, relative to the major G allele, appears to be both a risk factor for nicotine dependence and a protective factor for cocaine dependence.
|
18519132 |
2008 |
|
rs10052957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype 3 (including minor alleles of rs10052957 and rs41423247) was associated with an increased risk for cocaine addiction (odds ratio = 2.74, P < 0.05, uncorrected).
|
29761890 |
2019 |
|
rs2283265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The influence of DRD2 rs2283265 and DRD4 48 bp VNTR in exon 3 variants, as well as their interaction on crack cocaine addiction susceptibility and severity were evaluated in women and men separately.
|
30367264 |
2019 |
|
rs41423247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype 3 (including minor alleles of rs10052957 and rs41423247) was associated with an increased risk for cocaine addiction (odds ratio = 2.74, P < 0.05, uncorrected).
|
29761890 |
2019 |
|
rs1868152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence.
|
29715653 |
2018 |
|
rs2952621
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence.
|
29715653 |
2018 |
|
rs2229163
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (Pcorrected = 0.047).
|
27269905 |
2016 |
|
rs1437134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of SNP rs1437134 with cocaine dependence survived the Bonferroni correction for multiple testing.
|
26506053 |
2015 |
|
rs13273442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
rs149775276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, one variant (rs149775276; H329Y) shows association with both cocaine dependence symptoms (P = 7.4 × 10(-5), β = 2.04) and alcohol dependence symptoms (P = 2.6 × 10(-4), β = 2.04).
|
24057674 |
2014 |
|
rs149775276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, one variant (rs149775276; H329Y) shows association with both cocaine dependence symptoms (P = 7.4 × 10(-5), β = 2.04) and alcohol dependence symptoms (P = 2.6 × 10(-4), β = 2.04).
|
24057674 |
2014 |
|
rs1611115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.
|
24809448 |
2014 |