|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we report that the expression of FAD-linked PS1 M146V mutant affects store-operated calcium channel activity (Isoc) in human neuroblastoma SK-N-SH cells.
|
23624206 |
2013 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To elucidate the role of presenilin-1 in the Alzheimer's disease pathology, we tested two such mutations (P117L and M146L) for their effect in stably transfected mouse neuroblastoma cell lines.
|
11311782 |
2001 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines.
|
10400232 |
1999 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
To investigate the pathogenic mechanism of PS1 mutations linked to FAD, we established inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated PS1(M146L or deltaexon 10) under the control of the Lac repressor.
|
10360683 |
1999 |
|
rs63750306
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The influence of PS1 mutations on the generation of endogenous intracellular amyloid beta-protein (A beta) species was assessed using a highly sensitive immunoblotting technique with inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated PS1 (M146L or delta exon 10).
|
9751187 |
1998 |
|
rs63749805
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To elucidate the role of presenilin-1 in the Alzheimer's disease pathology, we tested two such mutations (P117L and M146L) for their effect in stably transfected mouse neuroblastoma cell lines.
|
11311782 |
2001 |
|
rs63749805
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines.
|
10400232 |
1999 |
|
rs63749805
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Human kidney 293 and mouse neuroblastoma N2a cells were stably transfected with wild-type and PS1 P117L.
|
9507958 |
1998 |
|
rs63751163
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We showed previously that PS1 exon 9 deletion (PS1 DeltaE9) and L250S mutations predispose SH-SY5Y neuroblastoma cells to high glucose stress-induced apoptosis and that the anti-apoptotic effect of insulin-like growth factor I (IGF-I) is compromised by these mutations.
|
11746362 |
2001 |
|
rs63751163
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
|
10658639 |
2000 |
|
rs1362575880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of these two mutations on presenilin-1 endoproteolysis and β-amyloid (Aβ) production were examined in SH-SY5Y neuroblastoma cells infected with lentiviruses expressing presenilin-1 wild type (WT), I249L and P433S mutants.
|
31235249 |
2019 |
|
rs63750852
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.
|
16916581 |
2006 |
|
rs63751235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined the effects of overexpression of presenilin-1 wild-type (PS1wt) or mutant L286V (PS1m) in human neuroblastoma SH-SY5Y cells on signal transduction systems.
|
11382407 |
2001 |
|
rs63750646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we examined the effect of PSEN1 1143T and G384A mutations on tau phosphorylation in human SH-SY5Y and mouse Neuro-2a neuroblastoma cell lines that were transiently transfected with wild type (WT) or mutant PSEN1.
|
10430510 |
1999 |