|
rs1800042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the hypothesis that the 5-HT1A receptor-induced serotonergic dysfunction is implicated genetically in suicide, we focused on the structural polymorphisms, Pro16Leu and Gly272Asp, of the 5-HT1A receptor gene, and examined the association between suicide victims who completed suicide and these two polymorphisms.
|
11992564 |
2002 |
|
rs1532976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05).
|
15838597 |
2005 |
|
rs3752826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05).
|
15838597 |
2005 |
|
rs9393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05).
|
15838597 |
2005 |
|
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively).
|
18250953 |
2008 |
|
rs734312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The nonsynonymous variants rs1383180 in EVC gene, rs6811863 in TBC1D1 gene, rs362272 in HTT gene, and rs734312 in WFS1 gene were associated to the male completed suicide.
|
19115052 |
2009 |
|
rs2682826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that both the genotypic distribution and the allelic frequencies of rs2682826 SNP were significantly different between the completed suicide and control groups (P=0.0007 and 0.0005, respectively).
|
20470850 |
2010 |
|
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
|
rs1360780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
|
rs6295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
|
21397953 |
2011 |
|
rs10416814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied 5 SNPs including one SNP in exon 2 (rs3745459) and four SNPs in the potential promoter region of the EP1 gene (rs3810255, rs3810254, rs3810253 and rs10416814) in 374 healthy control and 287 completed suicide victims using standard Taqman probe genotyping assays.
|
21447366 |
2011 |
|
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide.
|
22211341 |
2012 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
|
rs10868235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
|
rs4307059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC genotype of rs4307059 located in the region between CDH9 and CDH10 is associated with completed suicide in a Polish cohort.
|
22846907 |
2012 |
|
rs930752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that MTHFR C677T polymorphism is not a risk factor for completed suicide.
|
22982411 |
2012 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism (rs1801133) was associated with numerous psychiatric conditions but no prior study investigated whether it predisposes to completed suicide.
|
22982411 |
2012 |
|
rs6943555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that rs6943555 might be associated with completed suicide.
|
23437340 |
2013 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.
|
23850432 |
2013 |
|
rs759834365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.
|
23850432 |
2013 |
|
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide.
|
24289909 |
2014 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study proves that there is an inverse association between rs9939609 polymorphism in FTO gene and completed suicide which is independent from association between FTO and alcohol addiction.
|
25265168 |
2014 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |