rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our previous work showed an association of the single nucleotide polymorphism (SNP) rs6265 in the BDNF gene with completed suicide in the Slavic population.
|
26462037 |
2015 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.
|
23850432 |
2013 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
When we analyzed suicidal behavior, we found a significant association with the rs1360780 of FKBP5 and suicidal behavior risk in the overall population and rs3800373 in completed suicide subgroup.
|
30791339 |
2019 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A significant association between the high-induction rs3800373 C allele and completed suicide was detected (OR = 1.36, p = 0.007).
|
26630184 |
2015 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
rs1360780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When we analyzed suicidal behavior, we found a significant association with the rs1360780 of FKBP5 and suicidal behavior risk in the overall population and rs3800373 in completed suicide subgroup.
|
30791339 |
2019 |
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide.
|
22211341 |
2012 |
rs1360780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively).
|
18250953 |
2008 |
rs121908538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs181058279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs4073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele of rs4073 was significantly over-represented in suicide attempt group compared with both control and completed suicide groups (adjusted P values of 8.3E-7 and 9.8E-8 respectively).
|
30099207 |
2018 |
rs745918508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs76215382
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs12273363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs1491850
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs1491851
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs7124442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs908867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs962369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide.
|
24289909 |
2014 |
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study proves that there is an inverse association between rs9939609 polymorphism in FTO gene and completed suicide which is independent from association between FTO and alcohol addiction.
|
25265168 |
2014 |