|
rs2287622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A common variant (rs2287622; p.V444A) in the gene encoding BSEP has been associated with an increased risk of cholestatic DILI.
|
30608704 |
2019 |
|
rs10946737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the basis of this case-control study, SNP rs10946737 in FAM65B may be associated with susceptibility to ATDH in Chinese Han anti-TB treatment patients.
|
30720667 |
2019 |
|
rs117806152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs79280755 increased the risk of ATDILI significantly whether in additive (OR = 3.218, 95% CI: 1.686-6.139, PBonferroni correction = .003) or dominant model (PBonferroni correction = .003), as well as rs117806152 (Additive model: PBonferroni correction = .05; dominant model: PBonferroni correction = .03).
|
31689868 |
2019 |
|
rs2306283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction.
|
31240859 |
2019 |
|
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated idiosyncratic DILI with rs2476601, a nonsynonymous polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phosphatase, nonreceptor type 22 gene (PTPN22) (odds ratio [OR] 1.44; 95% confidence interval [CI] 1.28-1.62; P = 1.2 × 10<sup>-9</sup> and replicated the finding in the validation set (OR 1.48; 95% CI 1.09-1.99; P = .01).
|
30664875 |
2019 |
|
rs4148323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction.
|
31240859 |
2019 |
|
rs4430924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for weight and hepatoprotectant use, conditional logistic regression analysis showed that patients carrying the AA genotype of rs4430924 in</span> XPO1 were at higher risk of anti-TB drug-induced hepatotoxicity than those carrying the GG genotype based on the subgroup of probable cases (adjusted OR, 1.938; 95%CI, 1.035-3.628; P = .039), and marginally significant differences were also found under the recessive model (P = .048) and the additive model (P = .047).
|
30817003 |
2019 |