Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients. 28848102

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients. 28848102

2018

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender. 26813412

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This study showed the involvement of A1298C, Val158Met and their interaction in MDD. 26021967

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls. 26117067

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response. 26976307

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls. 26117067

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. 25745134

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Among the various candidate genes implicated in MDD, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 5-HT transporter gene linked polymorphism (5-HTTLPR) have garnered the most attention due to their putative roles in neural plasticity and antidepressant response. 26976307

2016

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD. 25766270

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val66Met polymorphism and child adversity. 25044977

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The aim of this study was to determine which hippocampal dentate gyrus and cornu ammonis subfields are altered in MDD compared to healthy controls and which subfields are affected by the BDNF Val66Met polymorphism and child adversity. 25044977

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. 25510949

2015

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. 24751310

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls. 22965830

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls. 22965830

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome. 23165919

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE To examine whether the polymorphisms of BDNF (rs6265) and NTRK2 (rs1387923, rs2769605 and rs1565445) genes confer risk for TRD in major depressive disorder (MDD), a total of 948 MDD patients were recruited in a 12-week, multicenter, prospective longitudinal study. 23137999

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. 23184535

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The aim of our two-center study was to determine how the BDNF Val66Met polymorphism and childhood adversity affect the volumetric measures of the hippocampus in healthy individuals and people with MDD. 23341118

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD). 22883353

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Common genetic variants, such as the brain-derived neurotrophic factor (BDNF) Val/66/Met polymorphism (rs6265), are known to interact with environmental factors such as early adversity to increase the risk of subsequent major depression. 22844024

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The aim of our study was to evaluate the association of regional gray matter (GM) volume within the hippocampus and other unpredicted regions at the whole-brain level with the BDNF Val66Met polymorphism in MDD patients with melancholic features and their impact on treatment outcome. 23165919

2013