Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12268840
rs12268840
MGMT
0.010 GeneticVariation BEFREE Homozygous carriers of MGMT rs12268840 with frequent acid reflux had significantly higher risks of EAC (OR 15.5, 95% CI 5.8-42) than expected under an additive model, consistent with biological interaction (S = 3.3, 95% CI 1.1-10). 18386788

2008
dbSNP: rs12269324
rs12269324
MGMT
0.010 GeneticVariation BEFREE We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (K751Q). 18386788

2008
dbSNP: rs12917
rs12917
MGMT ; LOC105378560
0.010 GeneticVariation BEFREE We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (K751Q). 18386788

2008
dbSNP: rs13181
rs13181
ERCC2 ; KLC3
0.010 GeneticVariation BEFREE No associations with EAC or EGJAC were observed with XPD (rs13181). 18386788

2008
dbSNP: rs1501299
rs1501299
ADIPOQ ; ADIPOQ-AS1
0.010 GeneticVariation BEFREE Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. 18398047

2008
dbSNP: rs2308321
rs2308321
MGMT
0.010 GeneticVariation BEFREE Potential biological interaction was assessed through the synergy index S. Each MGMT SNP conferred increased risks of EAC but not EGJAC; strongest associations were found for the 2 variant MGMT alleles rs12268840 and I143V (p = 0.005 and p < 0.001, respectively). 18386788

2008
dbSNP: rs2308327
rs2308327
MGMT
0.010 GeneticVariation BEFREE We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (K751Q). 18386788

2008
dbSNP: rs25487
rs25487
XRCC1
0.010 GeneticVariation BEFREE We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (K751Q). 18386788

2008
dbSNP: rs696217
rs696217
GHRL ; GHRLOS
0.010 GeneticVariation BEFREE Although several SNPs seemed to be associated with EAC on crude analysis [ADIPOQ (rs1501299), LEP (5'-untranslated region), PPARgamma (H447H), and GHRL (M72L)], effect sizes were modest and none of the associations was significant after correcting for multiple comparisons. 18398047

2008
dbSNP: rs759412116
rs759412116
ERCC2
0.010 GeneticVariation BEFREE We compared patients with EAC (n = 263) or EGJAC (n = 303) with matched population controls (n = 1,337) for the frequency of 5 MGMT single nucleotide polymorphisms (SNPs) (rs12269324, rs12268840, L84F, I143V, K178R), as well as SNPs in DNA repair genes ERCC1 (N118N), XRCC1 (Q399R) and XPD (K751Q). 18386788

2008