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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose.
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19010884 |
2008 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that there are at least two distinct mechanisms conferring risk for nicotine dependence and lung cancer: altered receptor function caused by a D398N amino acid variant in CHRNA5 (rs16969968) and variability in CHRNA5 mRNA expression.
|
19443489 |
2009 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also examined the association of CHRNA5 D398N polymorphism with lung cancer risk and with CHRNA5 mRNA levels in the normal lung.
|
19223495 |
2009 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10(-20)) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968.
|
20700436 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified.
|
19577767 |
2010 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, P(trend) = 2 x 10(-26)), and this association was stronger for those diagnosed at younger ages.
|
20548021 |
2010 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a total of 17 300 subjects from five LC studies and four upper aerodigestive tract (UADT) cancer studies.
|
19776245 |
2010 |
|
rs11637635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs17408276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs17486278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk.
|
20587604 |
2010 |
|
rs481134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer.
|
20395203 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lun</span>g cancer patients who were never-smokers, based on a small sample.
|
21750227 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs16969968-lung cancer association did not differ by intake level of most dietary factors examined, but was stronger for individuals diagnosed at < 70 years of age or having a baseline smoking history of <40 cigarette pack-years.
|
21229299 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two variants in the nicotinic acetylcholine receptor subunit genes CHRNA5 and CHRNA3 on 15q25, rs16969968 and rs578776, were associated with cotinine (P = 0.001 and 0.03, respectively) in current smokers and with lung cancer risk (P < 0.001 and P = 0.001, respectively).
|
21862624 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diplotype analysis of rs3841324 with either rs16969968 or rs8034191 showed that these polymorphisms influenced the lung cancer risk independently.
|
22028403 |
2011 |
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rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The A allele of the SNP rs16969968 (alpha5, G>A), which correlates with the development of lung cancer, shows a non-significant trend to be associated with cervical lesions.
|
22406075 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional SNP associations were observed on 15q25.1 in genes previously associated with lung cancer, including a missense variant in CHRNA5 (rs16969968: OR = 1.60, 95% CI = 1.27-2.01, P = 5.9 x 10-5).
|
23232035 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A rare variant of chromosomal region 15q25.1, marked by rs16969968 (substitution 1354G>A in CHRNA5), was found to be associated with increased lung cancer and nicotine-dependence risk.
|
21955800 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).
|
22534784 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association with lung cancer risk was found for CHRNA5 rs16969968.
|
23178447 |
2013 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results also confirm and extend previous findings for associations between rs16969968 and lung cancer, loss of lung function equivalent to that of COPD, and smoking quantity.
|
23443019 |
2013 |
|
rs3829787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two of the polymorphisms (rs3829787 and rs3841324) statistically influenced the risk of developing lung cancer.
|
23011884 |
2013 |
|
rs503464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the heterozygous genotype c.-166T>A at rs503464 of CHRNA5 may be associated with reduced risk of lung cancer, thus representing a susceptibility allele in Chinese individuals.
|
23314339 |
2013 |
|
rs667282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we did not observe a significant association of each genotype of the two SNPs with risk of gastric cancer (TT/CT vs. CC: adjusted OR = 1.12,95 % CI = 0.86-1.45; p = 0.401 for rs667282 and GG/TG vs. TT: adjusted OR = 1.13,95 % CI = 0.90-1.43; p = 0.300 for rs3743073).The results of our study indicated that these two SNPs at the 15q25 locus did not modify gastric cancer risk and the reported risk SNP at 15q25 may be specific to lung cancer.
|
23576140 |
2013 |