|
rs11637635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs17408276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A rare variant of chromosomal region 15q25.1, marked by rs16969968 (substitution 1354G>A in CHRNA5), was found to be associated with increased lung cancer and nicotine-dependence risk.
|
21955800 |
2012 |
|
rs588765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers.
|
26282330 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers.
|
26282330 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional SNP associations were observed on 15q25.1 in genes previously associated with lung cancer, including a missense variant in CHRNA5 (rs16969968: OR = 1.60, 95% CI = 1.27-2.01, P = 5.9 x 10-5).
|
23232035 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, P(trend) = 2 x 10(-26)), and this association was stronger for those diagnosed at younger ages.
|
20548021 |
2010 |
|
rs17486278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk.
|
20587604 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diplotype analysis of rs3841324 with either rs16969968 or rs8034191 showed that these polymorphisms influenced the lung cancer risk independently.
|
22028403 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, these results suggest that the association between rs16969968 and lung cancer may be mediated by the quantity of smoke inhaled.
|
23358500 |
2014 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.
|
25873736 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lun</span>g cancer patients who were never-smokers, based on a small sample.
|
21750227 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10(-20)) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968.
|
20700436 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association with lung cancer risk was found for CHRNA5 rs16969968.
|
23178447 |
2013 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis provided statistical evidence for a strong association between rs16969968 polymorphism and the risk of lung cancer, especially in smokers and Caucasians.
|
26434895 |
2015 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results also confirm and extend previous findings for associations between rs16969968 and lung cancer, loss of lung function equivalent to that of COPD, and smoking quantity.
|
23443019 |
2013 |
|
rs667282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we did not observe a significant association of each genotype of the two SNPs with risk of gastric cancer (TT/CT vs. CC: adjusted OR = 1.12,95 % CI = 0.86-1.45; p = 0.401 for rs667282 and GG/TG vs. TT: adjusted OR = 1.13,95 % CI = 0.90-1.43; p = 0.300 for rs3743073).The results of our study indicated that these two SNPs at the 15q25 locus did not modify gastric cancer risk and the reported risk SNP at 15q25 may be specific to lung cancer.
|
23576140 |
2013 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, to identify genetic factors that modify lung cancer risk, CHRNA5 non-synonymous variant amino acid position 398 (D398N) was identified.
|
19577767 |
2010 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population
|
29172281 |
2017 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies link a gene cluster encoding for α3β4α5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence.
|
28045487 |
2017 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs16969968-lung cancer association did not differ by intake level of most dietary factors examined, but was stronger for individuals diagnosed at < 70 years of age or having a baseline smoking history of <40 cigarette pack-years.
|
21229299 |
2011 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The A allele of the SNP rs16969968 (alpha5, G>A), which correlates with the development of lung cancer, shows a non-significant trend to be associated with cervical lesions.
|
22406075 |
2012 |
|
rs16969968
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The increase in cotinine levels indicated an increased risk of lung cancer with each additional copy of the rs1051730-rs16969968 risk allele (per-allele odds ratio = 1.31, 95% CI = 1.21 to 1.42).
|
22534784 |
2012 |