|
rs1214285376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population.
|
27323144 |
2016 |
|
rs2307181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population.
|
25433331 |
2015 |
|
rs2307191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population.
|
25433331 |
2015 |
|
rs2854509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two polymorphisms (rs2854509 and rs7248167) that were predicted to affect XRCC1 expression based on their RegulomeDB scores were not associated with lung cancer risk (P = 0.31 and 0.93, respectively).
|
25592768 |
2015 |
|
rs148611340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A and genotype AA of c.1161G>A and allele G and genotype GG of c.177</span>9C>G genetic variants may enhance lung cancer susceptibility.
|
25146668 |
2014 |
|
rs199613843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele A and genotype AA of c.1161G>A and allele G and genotype GG of c.1779C>G genetic variants may enhance lung cancer susceptibility.
|
25146668 |
2014 |
|
rs200842482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The XRCC1 c.1178G>A genetic polymorphism was associated with an increased risk of lung cancer (AA vs GG: OR=2.91, 95%CI 1.70-4.98, p<0.001; A vs G: OR=1.52, 95%CI 1.22-1.90, p<0.001).
|
24935603 |
2014 |
|
rs72554204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, these results showed that the functional c.1471G>A genetic polymorphism of XRCC1 was associated with lung cancer susceptibility in the studied population.
|
24519065 |
2014 |
|
rs3213245
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, four polymorphisms of XRCC1 (rs25487, rs25489, rs1799782, and rs3213245), which were investigated with regard to their association with lung cancer risk in previous studies, were also genotyped.
|
25592768 |
2015 |
|
rs3213245
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, there is a significant association of XRCC1 rs3213245 polymorphism with lung cancer risk.
|
24470137 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CONCLUSIONS Taken together, T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women, with the factors of occupation type, cooking-oil fumes, and soot exposures representing key contributing factors.
|
30109864 |
2018 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was found between SULT1A1 rs9282861 and XRCC1 rs25487 polymorphisms and lung cancer risk.
|
29110586 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).
|
27819744 |
2016 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, four polymorphisms of XRCC1 (rs25487, rs25489, rs1799782, and rs3213245), which were investigated with regard to their association with lung cancer risk in previous studies, were also genotyped.
|
25592768 |
2015 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.
|
25563194 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population.
|
25684477 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data demonstrated that the SNPs rs25487</span> and rs1052133 are risk factors for l</span>ung cancer in epidemiologically susceptible Chinese people.
|
26634519 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure.
|
25300687 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.
|
25563194 |
2015 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the four polymorphisms that were previously studied, only rs25489 of XRCC1 was significantly associated with lung cancer risk (dominant model, adjusted odds ratio = 0.61, 95% confidence interval = 0.46-0.83, P = 0.002).
|
25592768 |
2015 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians.
|
25064613 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms that xrcc1 rs1799782 may lower the risk of lung cancer among Caucasians.
|
25038912 |
2014 |