|
rs2735940
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TERT rs2735940 polymorphism was significantly associated with cancer risk, especially lung cancer.
|
25716168 |
2015 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
|
rs2853677
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The association with rs2853677 is driven by the adenocarcinoma subtype of lung cancer (p=1.3×10(-8); OR=1.37; 95% CI=1.23-1.54).
|
27393504 |
2016 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The effect of rs2853669 on lung cancer</span> risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02).
|
26425038 |
2015 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
|
29534075 |
2018 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of this study suggested that rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.
|
25966219 |
2015 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
rs2735940
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations.
|
24761905 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT-rs2736098 T allele was also associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma.
|
24861918 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
|
24283584 |
2013 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence.
|
28827732 |
2017 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two glioma risk variants, TERT rs2853676 and CDKN2BAS1 rs4977756, which are located in regions previously associated with lung cancer, were associated with increased risk of adenocarcinoma (OR = 1.16; 95% CI = 1.10 to 1.22; P = 1.1×10(-8)) and squamous cell carcinoma (OR = 1.13; CI = 1.07 to 1.19; P = 2.5×10(-5)), respectively.
|
24681604 |
2014 |
|
rs4246742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the χ2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60-0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01-1.57; P=0.045).
|
25254308 |
2014 |
|
rs2853672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the χ2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60-0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01-1.57; P=0.045).
|
25254308 |
2014 |
|
rs144779807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
|
rs2853677
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed that variant rs2853677 was strongly associated with lung cancer and leukemia risk with an odds ratio (OR) =1.8 (1.03-3.2 at 95% CI); p value (adjusted) = 0.03; odds ratio (OR) =2.9 (1.4-5.5.at 95% CI); p value (adjusted) = 0.002, respectively.
|
31126249 |
2019 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies.
|
25516442 |
2015 |