|
rs1800624
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Haplotype C-A-A (alleles in order of rs1800625, rs1800624 and rs2070600) of RAGE gene was overrepresented in patients, and conferred a 2.1-fold increased risk of lung cancer (95% confidence interval: 1.52-2.91), independent of confounding factors.
|
23874853 |
2013 |
|
rs1800625
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the gene encoding RAGE (<i>AGER</i>), there are three well-known polymorphisms; rs2070600, rs1800624, and rs1800625, which potentially increase the risk of lung cancer.
|
29212235 |
2017 |
|
rs1800625
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype C-A-A (alleles in order of rs1800625, rs1800624 and rs2070600) of RAGE gene was overrepresented in patients, and conferred a 2.1-fold increased risk of lung cancer (95% confidence interval: 1.52-2.91), independent of confounding factors.
|
23874853 |
2013 |
|
rs595961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, this is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk.
|
27669275 |
2016 |
|
rs2066853
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We also observed statistically significant interaction between the polymorphism rs2066853 (p.Arg554Lys) and cumulative cigarette smoking as a discrete or continuous variable (P=0.033 and 0.019, respectively), and the Lys/Lys genotype conferred an increased risk of lung cancer in the heavy smokers (adjusted odds ratio=3.36 and 95% confidence interval=1.07-10.55).
|
18818557 |
2009 |
|
rs2066853
|
|
|
0.030 |
GeneticVariation |
BEFREE |
SQCC individuals with mutant genotype of rs2066853 also exhibited a protec-tive effect towards lung cancer (OR=0.30, p=0.0013).
|
29755293 |
2018 |
|
rs2066853
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Of all the genetic variants, XRCC1 632, GSTM1 and AhR rs2066853 was the most important determinant of overall survival of lung cancer patients CONCLUSION: Through the study we introduced the concept of polygenic approach to get an insight about the various polymorphic variants in determining cancer susceptibility.
|
29412865 |
2018 |
|
rs7811989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To study the role of AhR variants (rs2282885, rs10250822, rs7811989, rs2066853) in affect-ing lung cancer susceptibility.
|
29755293 |
2018 |
|
rs7811989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that significantly increased lung cancer risk was associated with heterozygous genotypes of rs2158041 (adjusted odds ratio=1.53 and 95% confidence interval=1.17-1.99 for GA, compared with the GG genotype) and rs7811989 (adjusted odds ratio=1.48 and 95% confidence interval=1.13-1.93 for GA, compared with the GG genotype), although these two single-nucleotide polymorphisms were in linkage disequilibrium.
|
18818557 |
2009 |
|
rs2158041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that significantly increased lung cancer risk was associated with heterozygous genotypes of rs2158041 (adjusted odds ratio=1.53 and 95% confidence interval=1.17-1.99 for GA, compared with the GG genotype) and rs7811989 (adjusted odds ratio=1.48 and 95% confidence interval=1.13-1.93 for GA, compared with the GG genotype), although these two single-nucleotide polymorphisms were in linkage disequilibrium.
|
18818557 |
2009 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data provide evidence that, although AKT1 mutations are apparently rare in lung cancer (1.9%), the oncogenic properties of E17K-AKT1 may contribute to the development of a fraction of lung carcinoma with squamous histotype (5.5%).
|
18256540 |
2008 |
|
rs778561687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MEK1 mutation (K57K) was found from 1 of 280 patients with lung cancer (0.4%) and detected only one case (0.4%) of AKT2 mutation (R371H) in our cohort.
|
20354455 |
2010 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine possible interaction between smoking and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism (rs671) on the risk of lung cancer in Japanese.
|
20093384 |
2010 |
|
rs1057519697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Molecular dynamics simulations reveal the allosteric effect of F1174C resistance mutation to ceritinib in ALK-associated lung cancer.
|
27764703 |
2016 |
|
rs1057519784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we report that both <i>ALK</i>-mutant L1196M and EMT were concomitantly detected in a single crizotinib-resistant lesion in a patient with <i>ALK</i>-rearranged lung cancer.
|
30737231 |
2019 |
|
rs1654701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We checked the interaction effect on the ANGPT1 expression and lung cancer and found that the minor allele "G" of rs1654701 increased ANGPT1 gene expression and decreased lung cancer risk with the increased dosage of "A" of rs4262299, which consistent with the tumor suppressor function of ANGPT1.
|
31385379 |
2019 |
|
rs4262299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We checked the interaction effect on the ANGPT1 expression and lung cancer and found that the minor allele "G" of rs1654701 increased ANGPT1 gene expression and decreased lung cancer risk with the increased dosage of "A" of rs4262299, which consistent with the tumor suppressor function of ANGPT1.
|
31385379 |
2019 |
|
rs11137037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the variant GT allele of rs12674822 had a higher risk of lung cancer than wild-type (GG) carriers, while the presence of the CC genotype at rs11137037 was associated with higher clinical stage disease compared with having the AA genotype.
|
31281470 |
2019 |
|
rs12674822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five Ang2 SNPs (rs2442598, rs734701, rs1823375, 11137037, and rs12674822</span>) were analyzed using TaqMan SNP genotyping in 695 patients with lung cancer and 900 cancer-free controls.
|
31281470 |
2019 |
|
rs1060503291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three common coding region (V22M, Q324H and S501F) and intronic (157+30A>G, 462+35G>A and 1435-40G>C) variants, but none were over-represented in the patient samples, indicating that MYH variants are unlikely to predispose significantly to the risk of lung cancer.
|
14579148 |
2004 |
|
rs776197565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three common coding region (V22M, Q324H and S501F) and intronic (157+30A>G, 462+35G>A and 1435-40G>C) variants, but none were over-represented in the patient samples, indicating that MYH variants are unlikely to predispose significantly to the risk of lung cancer.
|
14579148 |
2004 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined effect of smoking and presence of the APEX1 Asp148Glu demonstrated a significant association with risk of lung cancer (adjusted OR 3.61, 95% CI 1.74-7.50, p=0.001).
|
21198260 |
2010 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The hOGG1 Ser326Cys polymorphism is associated with lung cancer risk, but there are limited data regarding an association between the APE1 Asp148Glu polymorphism and lung cancer.
|
23038158 |
2012 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results provide evidence that the non-synonymous polymorphis</span>m of APEX1 Asp(148)Glu may not be directly associated with lung cancer</span> risk, nor enhance the effects of smoking habit on lung cancer development.
|
23749940 |
2013 |
|
rs1130409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with lung cancer risk among Asians or Caucasians.
|
21132382 |
2011 |