|
rs1799945
|
|
|
0.020 |
GeneticVariation |
BEFREE |
.To test the hypothesis that possession of either C282Y or H63D mutations in the HFE gene is associated with primary osteoarthritis (OA) in joints commonly affected in hemochromatotic arthropathy.
|
16583477 |
2006 |
|
rs1799945
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype.
|
16755236 |
2006 |
|
rs2228611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC genotypes of rs2228611 and rs2228612 of DNMT1 were associated with a lower risk for primary knee OA under a co-dominant and a recessive model [OR (95% CI) 0.4 (0.2-0.8)/0.5 (0.3-0.8) and 0.3 (0.1-0.8)/0.3 (0.1-0.7), respectively].
|
31713648 |
2020 |
|
rs2228612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CC genotypes of rs2228611 and rs2228612 of DNMT1 were associated with a lower risk for primary knee OA under a co-dominant and a recessive model [OR (95% CI) 0.4 (0.2-0.8)/0.5 (0.3-0.8) and 0.3 (0.1-0.8)/0.3 (0.1-0.7), respectively].
|
31713648 |
2020 |
|
rs11096957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR10 SNP rs11096957 was found significantly associated with predisposition to hip OA (p = 0.04, OR = 1.41, 95%CI = 1.02-1.94) but not knee OA.
|
29194748 |
2018 |
|
rs16872158
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After combining the two stages, we found that rs4730153 was significantly associated with decreased risk of OA in an additive genetic model (P < 0.05), while rs16872158 showed increased risk of developing OA (P < 0.05).
|
26752339 |
2016 |
|
rs2058540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in PBEF1 and evaluated the association between the genetic variants and OA risk in a two-stage case-control study including 196 cases and 442 controls in the first stage and 143 cases and 238 controls in the second stage.
|
26752339 |
2016 |
|
rs3801267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in PBEF1 and evaluated the association between the genetic variants and OA risk in a two-stage case-control study including 196 cases and 442 controls in the first stage and 143 cases and 238 controls in the second stage.
|
26752339 |
2016 |
|
rs4730153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After combining the two stages, we found that rs4730153 was significantly associated with decreased risk of OA in an additive genetic model (P < 0.05), while rs16872158 showed increased risk of developing OA (P < 0.05).
|
26752339 |
2016 |
|
rs2277831
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the tissues that we have studied, our data do not support our hypothesis that the association between rs2277831 and OA is due to the effect this SNP has on MICAL3, BCL2L13 or BID gene expression.
|
22385522 |
2012 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
.To test the hypothesis that possession of either C282Y or H63D mutations in the HFE gene is associated with primary osteoarthritis (OA) in joints commonly affected in hemochromatotic arthropathy.
|
16583477 |
2006 |