|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an independent association of C2/CFB variants was found for both typical AMD and PCV with age, sex, smoking, and genetic background of ARMS2 A69S and CFH I62V (vs. typical AMD: P = 0.0073, odds ratio [OR] = 0.47; vs. PCV: P = 0.0083, OR = 0.53).
|
22232432 |
2012 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis provides substantial evidence that the ARMS2 A69S variant confers a significantly higher risk of neovascular AMD than PCV.
|
22219653 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotyping of ARMS2 A69S is more informative than that of CFH I62V in understanding the clinical features in patients with PCV.
|
21397333 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the multivariate regression analysis, the additive model of the G allele at rs10490924</span> was associated with a significantly better BCVA 12 months after the first PDT in tAMD and PCV patients.
|
21541271 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p.Ala69Ser polymorphism of the ARMS2 gene is strongly associated with exudative AMD and PCV and is associated marginally with dry AMD.
|
21236409 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Severe vision-threatening complications (ie, suprachoroidal hemorrhage, vitreous hemorrhage, and tears of the retinal pigment epithelium) were seen only in eyes with larger PCV, and in studying single nucleotide polymorphisms A69S of ARMS2 genes, there was a significant difference in T allele frequency between individuals with smaller PCV and those with larger PCV (20.2% vs 79.8%; P = .0235).
|
21457926 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, the distributions of rs10490924 did not differ between the typical PCV and control groups.
|
21896867 |
2011 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polypoidal CNV group included no subjects homozygous for the A/A genotype of rs800292, whereas 7% of the typical PCV group had this genotype.
|
21896867 |
2011 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotyping of ARMS2 A69S is more informative than that of CFH I62V in understanding the clinical features in patients with PCV.
|
21397333 |
2011 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four AMD-associated haplotype-tagging alleles (rs547154, rs1061170, rs1410996, rs10490924) in the 3 major loci, CFH, CFB/C2, and ARMS2/HTRA1, also were statistically significantly associated with the PCV phenotype (P<0.05).
|
20378180 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms responsible for nAMD and PCV may be located in this region or in the strong linkage disequilibrium of rs10490924 and rs11200638.
|
21191724 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ARMS2 A69S has a strong association with all three subtypes, with the association being strongest for RAP and weakest for PCV.
|
20574013 |
2010 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms responsible for nAMD and PCV may be located in this region or in the strong linkage disequilibrium of rs10490924 and rs11200638.
|
21191724 |
2010 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CFH Y402H is associated with AMD, tAMD, and PCV, whereas I62V is associated with all three subtypes.
|
20574013 |
2010 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The LOC387715 A69S genotype is not associated with lesion composition or size on indocyanine green angiography but with lesion size on fluorescein angiography in patients with subfoveal polypoidal choroidal vasculopathy.
|
19898184 |
2009 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The nonsynonymous variant I62V is a plausible candidate for a causal polymorphism leading to the development of PCV, given its potential for functional consequences on the CFH protein and our own statistical evidence.
|
19187823 |
2009 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The AA genotype of rs11200638 and TT genotype of rs10490924 conferred a 4.9-fold (95% CI: 1.85-12.95) and 4.89-fold (95% CI: 1.85-12.90) increased risk of PCV, respectively, after adjustment for age and sex.
|
18515590 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs3753394 and rs800292 of CFH and rs11200638 of HTRA1 are significantly associated with the risk of PCV in Chinese patients.
|
18515590 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
rs800292
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs3753394 and rs800292 of CFH and rs11200638 of HTRA1 are significantly associated with the risk of PCV in Chinese patients.
|
18515590 |
2008 |
|
rs10490924
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygotes for the risk allele at rs11200638 had a 6.33-fold increased risk of PCV and a 13.77-fold increased risk of wet AMD when compared with homozygotes for the wild-type allele.
|
17692272 |
2007 |
|
rs1061170
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The MAF of rs1061170 was not significantly different between either type of PCV and control (p = 0.084 and 0.15, respectively).
|
23289808 |
2013 |
|
rs1061170
|
|
|
0.060 |
GeneticVariation |
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |