|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative AMD (43.11 folds) than PCV (3.68 folds).
|
27338780 |
2016 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for rs11200638, ARMS2 rs10490924 remained significantly associated with nAMD and PCV (p<0.001).
|
23326481 |
2013 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are significantly associated with the risk of PCV in a Korean population.
|
21959923 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations with both exudative AMD and PCV were observed in 11 of them and HTRA1 rs11200638, with different genotypic distributions between exudative AMD and PCV (P < 0.001).
|
22491416 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
With meta-analyses, variants in four genes were found to be significantly associated with PCV: LOC387715 rs10490924 (n=9, allelic odds ratio [OR]=2.27, p<0.00001), HTRA1 rs11200638 (n=4, OR=2.72, p<0.00001), CFH rs1061170 (n=4, OR=1.72, p<0.00001), CFH rs800292 (n=5, OR=2.10, p<0.00001), and C2 rs547154 (n=3, OR=0.56, p=0.01).
|
22509112 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The polymorphisms responsible for nAMD and PCV may be located in this region or in the strong linkage disequilibrium of rs10490924 and rs11200638.
|
21191724 |
2010 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNPs rs3753394 and rs800292 of CFH and rs11200638 of HTRA1 are significantly associated with the risk of PCV in Chinese patients.
|
18515590 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygotes for the risk allele at rs11200638 had a 6.33-fold increased risk of PCV and a 13.77-fold increased risk of wet AMD when compared with homozygotes for the wild-type allele.
|
17692272 |
2007 |
|
rs1049331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs2293870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs2672598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that HTRA1 rs2672598 is more significantly associated with exudative AMD than PCV in ARMS2/HTRA1 region, and it is responsible for elevated HTRA1 transcriptional activity and HTRA1 protein expression.
|
27338780 |
2016 |
|
rs369149111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs3793917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant associations were found for six of the 19 SNPs with both typical nAMD and PCV (P < 1 × 10(-3)), peaking at a segment containing three of the SNPs: rs3793917, rs10490924, and rs11200638 (P < 10(-7)).
|
21191724 |
2010 |