Gene: EGFR ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE We report here a case of osimertinib used at 160 mg once daily in a heavily pretreated patient with EGFR exon 20 T790M-negative advanced NSCLC with LM to achieve a partial response, including shrinkage of the LM, for up to 12 months until further progression. 31642175

2019
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE T790M-positive patients with suspected LM after classical epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) failure were enroled. 29190637

2018
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE In this non-selected population, osimertinib had remarkable efficacy in NSCLC patients with LM irrespective of the presence of the EGFR-T790M-resistance mutation. 30039345

2018
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE Durable response to osimertinib in EGFR mutated T790M wildtype non-small cell lung cancer with leptomeningeal metastases: A case report. 29173769

2017
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE As this clinical entity is underrepresented in clinical trials, the practicability of plasma EGFR testing and the optimal dose-response relationship of osimertinib in T790M-positive lung cancer complicated with LM deserves further exploration. 28296233

2017
dbSNP: rs121434569
rs121434569
EGFR ; EGFR-AS1
0.060 GeneticVariation BEFREE In the multivariate analysis, statistically significant factors for longer PPS included T790M-positive, good performance status, and no carcinomatous meningitis. 24105277

2013
dbSNP: rs1057519847
rs1057519847
EGFR
0.030 GeneticVariation BEFREE We report three cases that were definitively diagnosed as LM from NSCLC with a mutation of epidermal growth factor receptor (<i>EGFR</i>) L858R. 31571928

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.030 GeneticVariation BEFREE In particular, the primary mutation, L858R, potentially predicts a higher risk of LM compared with deletion of exon 19. 30642536

2019
dbSNP: rs1057519848
rs1057519848
EGFR
0.030 GeneticVariation BEFREE We report three cases that were definitively diagnosed as LM from NSCLC with a mutation of epidermal growth factor receptor (<i>EGFR</i>) L858R. 31571928

2019
dbSNP: rs1057519848
rs1057519848
EGFR
0.030 GeneticVariation BEFREE In particular, the primary mutation, L858R, potentially predicts a higher risk of LM compared with deletion of exon 19. 30642536

2019
dbSNP: rs121434568
rs121434568
EGFR
0.030 GeneticVariation BEFREE We report three cases that were definitively diagnosed as LM from NSCLC with a mutation of epidermal growth factor receptor (<i>EGFR</i>) L858R. 31571928

2019
dbSNP: rs121434568
rs121434568
EGFR
0.030 GeneticVariation BEFREE In particular, the primary mutation, L858R, potentially predicts a higher risk of LM compared with deletion of exon 19. 30642536

2019
dbSNP: rs1057519847
rs1057519847
EGFR
0.030 GeneticVariation BEFREE We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on erlotinib maintenance therapy, and subsequently had leptomeningeal metastases that responded to gefitinib. 19015641

2009
dbSNP: rs1057519848
rs1057519848
EGFR
0.030 GeneticVariation BEFREE We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on erlotinib maintenance therapy, and subsequently had leptomeningeal metastases that responded to gefitinib. 19015641

2009
dbSNP: rs121434568
rs121434568
EGFR
0.030 GeneticVariation BEFREE We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on erlotinib maintenance therapy, and subsequently had leptomeningeal metastases that responded to gefitinib. 19015641

2009
dbSNP: rs121913428
rs121913428
EGFR
0.010 GeneticVariation BEFREE Notably, NGS of CSF was superior to genetic testing of peripheral blood at identifying an uncommon EGFR mutation (G719A) in a patient with NSCLC and leptomeningeal metastases. 31396478

2019
dbSNP: rs1302295057
rs1302295057
EGFR
0.010 GeneticVariation BEFREE We have recently identified an EGFR mutation E884K, in combination with L858R, in a patient with advanced lung cancer who progressed on erlotinib maintenance therapy, and subsequently had leptomeningeal metastases that responded to gefitinib. 19015641

2009