Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1048943
rs1048943
0.010 GeneticVariation BEFREE Hyperlipidemia could modulate the effect of CYP1A1 rs1048943 on the periodontal status of GAgP. 31032950

2019

dbSNP: rs419598
rs419598
0.010 GeneticVariation BEFREE The polymorphic expression of IL-1RN (rs419598) gene may be associated with a reduced susceptibility to GAgP and GCP in populations of European descent. 29023524

2017

dbSNP: rs30461
rs30461
0.010 GeneticVariation BEFREE Patients with periodontal health (n=30), chronic generalized periodontitis (n=30) and generalized aggressive periodontitis (n=30) were subjected to IL-29 quantity estimation in GCF and plasma using enzyme linked immunosorbent assay and was correlated with IL-29 SNP (rs30461) using polymerase chain reaction. 25255471

2015

dbSNP: rs312016
rs312016
0.010 GeneticVariation BEFREE Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis. 25329009

2015

dbSNP: rs429358
rs429358
0.010 GeneticVariation BEFREE Furthermore, individuals with the combined polymorphisms (LRP5-rs682429-AA and APOE-rs429358-CC/CT) had higher levels of low-density lipoprotein cholesterol, higher levels of TC and decreased odds for generalized aggressive periodontitis. 25329009

2015

dbSNP: rs682429
rs682429
0.010 GeneticVariation BEFREE Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis. 25329009

2015

dbSNP: rs953038635
rs953038635
0.010 GeneticVariation BEFREE Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease. 26718428

2015

dbSNP: rs4898
rs4898
0.010 GeneticVariation BEFREE On the basis of the present findings, it can be suggested that MMP-8 -799 C/T and TIMP-1 372 T/C, *429 T/G gene polymorphisms in males may be associated with the susceptibility to GAgP in the Turkish population. 24283658

2014

dbSNP: rs4073
rs4073
0.010 GeneticVariation BEFREE Genetic analysis of the IL8 gene polymorphism (rs4073) in generalized aggressive periodontitis. 22727395

2013

dbSNP: rs1267969615
rs1267969615
ACE
0.010 GeneticVariation BEFREE Present findings suggest that AGT M235T TT genotype and T allele might be associated with decreased risk for G-AgP in Turkish population. 19162259

2009

dbSNP: rs1333048
rs1333048
0.010 GeneticVariation BEFREE For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33-2.94; P = 6.9 x 10(-4)) for generalized aggressive periodontitis, and 1.72 (1.06-2.76; P = 2.6 x 10(-2)) for localized aggressive periodontitis. 19214202

2009

dbSNP: rs699
rs699
AGT
0.010 GeneticVariation BEFREE Present findings suggest that AGT M235T TT genotype and T allele might be associated with decreased risk for G-AgP in Turkish population. 19162259

2009

dbSNP: rs652438
rs652438
0.010 GeneticVariation BEFREE MMP-2 -735C/T and MMP-12 357Asn/Ser polymorphisms are not related to GAgP. 18052707

2007

dbSNP: rs1799983
rs1799983
0.010 GeneticVariation BEFREE The present study showed that eNOS Glu298Asp polymorphism is associated with BOP in GAgP patients. 16881803

2006

dbSNP: rs2066844
rs2066844
0.010 GeneticVariation BEFREE The mutant allele frequencies of the CARD15 variants were low in the generalized aggressive periodontitis group as well as in the control group and not significantly different (R702W: 3.5% versus 5.2%; G908R: 1.7% versus 1.5%; L1007fsX1008: 5.2% versus 4.5%). 16965521

2006

dbSNP: rs2066845
rs2066845
0.010 GeneticVariation BEFREE The mutant allele frequencies of the CARD15 variants were low in the generalized aggressive periodontitis group as well as in the control group and not significantly different (R702W: 3.5% versus 5.2%; G908R: 1.7% versus 1.5%; L1007fsX1008: 5.2% versus 4.5%). 16965521

2006