Gene: JAK1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs151047872
rs151047872
JAK1
A 0.700 GeneticVariation CLINVAR Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. 22955920

2012
dbSNP: rs1057519753
rs1057519753
JAK1
A 0.700 GeneticVariation CLINVAR Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. 21680795

2011
dbSNP: rs869312953
rs869312953
JAK1
T 0.700 GeneticVariation CLINVAR ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon. 20167706

2010
dbSNP: rs1057519753
rs1057519753
JAK1
A 0.700 GeneticVariation CLINVAR Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. 19838194

2009
dbSNP: rs1057519753
rs1057519753
JAK1
A 0.700 GeneticVariation CLINVAR JAK mutations in high-risk childhood acute lymphoblastic leukemia. 19470474

2009
dbSNP: rs1057519753
rs1057519753
JAK1
A 0.700 GeneticVariation CLINVAR Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. 19139102

2009