|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the subgroup analysis, we illustrated the effect of the H63D polymorphism on hepatocellular carcinoma and pancreatic cancer risk, particularly in the Asian and African subgroups; however, this was not observed in gynecological malignant tumors.
|
26535689 |
2015 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, in the stratified analysis by cancer type, an increased risk was identified in hepatocellular carcinoma and breast cancer in C282Y polymorphism, as well as pancreatic cancer in H63D polymorphism, whereas a decreased risk of colorectal cancer was identified in C282Y polymorphism.
|
26107216 |
2015 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hemochromatosis gene (HFE) mutations namely C282Y and H63D may cause hepatic iron overload, thus increasing the risk of HCC in HCV patients.
|
23845776 |
2013 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y homozygosity is associated with increased risk of colorectal cancer and hepatocellular cancer in men.
|
23281741 |
2013 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequencies of HD genotype of H63D mutation were significantly increased in HCC patients compared to control group and to cirrhosis group.
|
21925577 |
2011 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation.
|
20673159 |
2011 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SNPs (rs1800562 of HFE and rs2279744 of MDM2) were associated with HCC with moderate epidemiological evidence and deserve further study and additional biological and clinical assessment.
|
21240526 |
2011 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis.
|
20196837 |
2010 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis.
|
20196837 |
2010 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results show that H63D carriage is increased among hepatocellular carcinoma patients, suggesting that it may confer an increased susceptibility to hepatocellular carcinoma even in a heterozygous state.
|
18164971 |
2008 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Liver iron overload and C282Y mutation are associated with a higher risk of HCC in patients with alcoholic but not HCV-related cirrhosis.
|
18061182 |
2008 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the contrary, HFE C282Y and SERPINA1 mutations do not contribute to hepatocellular carcinoma development.
|
18164971 |
2008 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In multivariate analysis, H63D homozygotic mutation was an independent factor for the development of hepatocellular carcinoma (P = 0.004).
|
17410459 |
2007 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this population, we found that only a very small proportion of homozygotes for the HFE C282Y mutation developed hepatocellular carcinoma.
|
15929796 |
2005 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.
|
12865278 |
2003 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C282Y and the H63D mutation of the HFE gene were analyzed in 137 patients with HCC and no history of HH, 107 patients with cirrhosis without HCC and 126 healthy controls.
|
15017669 |
2003 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C282Y and H63D allele frequencies in HCC were 8.3 (95% confidence limit = 5.3-11.3) and 11.1 (7.8-14.6), respectively, and not different from previously published data in healthy subjects or patients with chronic hepatitis C in Austria.
|
12591066 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C282Y heterozygous genotype is significantly more common in HCC patients and is associated with significantly increased intrahepatic iron deposition and systemic iron stores.
|
15017669 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hepatocellular carcinoma was estimated to occur in 2673 men in the cohort (1:374); 267 of these cases were in the subgroup of 5000 C282Y homozygotes (1:17).
|
12790309 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Except for C282Y homozygotes, HFE gene mutations do not increase the risk to develop HCC in patients with cirrhosis.
|
12591066 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis.
|
12865278 |
2003 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between HFE gene mutations (C282Y, H63D) and hepatocellular carcinoma in patients with alcoholic and virus-related cirrhosis.
|
12003382 |
2002 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The high frequency of heterozygosity for the C282Y mutation in patients with alcoholic cirrhosis plus hepatocellular carcinoma suggests that the presence of this mutation could be associated with an increased risk of developing hepatocellular carcinoma in these patients.
|
12003382 |
2002 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of this study were to define the prevalence of the mutations 845G --> A and 187C --> G (C282Y and H63D) in the HFE gene associated with hereditary hemochromatosis in Italian patients with hepatocellular carcinoma occurring in cirrhosis and to analyze the interaction between these mutations and other established risk factors for hepatocellular carcinoma.
|
11500061 |
2001 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalence of the C282Y mutation was significantly higher in patients with hepatocellular carcinoma than in normal controls (8.6% vs 1.6%, P < 0.03).
|
11500061 |
2001 |