Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs80356779
rs80356779
CPT1A
0.010 GeneticVariation BEFREE The odds ratio (OR) for at least one hospitalization for any reason was increased for p.P479L homozygotes relative to noncarriers (OR=10.2, confidence interval [CI] 3.5 to 30.0) as were admissions for dental caries (OR=3.4, CI 1.5 to 7.8), acute lower respiratory tract infections (OR=6.0, CI 1.6 to 22.4), and otitis media (OR=13.5, CI 1.7 to 109.4). 30996616

2019
dbSNP: rs1800028
rs1800028
FUT2 ; LOC105447645
0.010 GeneticVariation BEFREE The common FUT2 c.604C>T (p.Arg202<sup>∗</sup>) variant co-segregates with otitis media in a Filipino pedigree (LOD = 4.0). 30401457

2018
dbSNP: rs766490137
rs766490137
NISCH
0.010 GeneticVariation BEFREE We also identified a second hypomorphic allele, V33A, with only modest increases in auditory thresholds and reduced incidence of OM. 28806779

2017
dbSNP: rs5030717
rs5030717
TLR4
0.010 GeneticVariation BEFREE In the initial Finnish cohort, the SNP rs5030717 in the TLR4 gene region showed significant association (OR 1.33, P = .003) to OM. 26177520

2015
dbSNP: rs3732378
rs3732378
CX3CR1
0.010 GeneticVariation BEFREE IL-1β (-31), CX3CR1 (Thr280Met), IL-10 (-1082) and IL-1β (-511) SNPs were associated with increased risk for frequent URIs or OM proneness. 24718616

2014
dbSNP: rs10497394
rs10497394 		0.010 GeneticVariation BEFREE We replicated the association of rs10497394 (GWAS discovery P = 1.30 × 10(-5)) on chromosome 2 in the independent otitis media population (P = 4.7 × 10(-5); meta-analysis P = 1.52 × 10(-8)). 23974705

2013