|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SULT1A1 (c.638G>A) was associated to infant acute lymphoblastic leukemia and acute myeloid leukemia (AML) risk in males (additive model: aOR = 0.52; 95% CI: 0.29-0.95, p = 0.03; dominant model: aOR = 2.18; 95% CI: 1.17-4.05, p = 0.01, respectively).
|
25992585 |
2015 |
|
rs1233753551
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SULT1A1 (c.638G>A) was associated to infant acute lymphoblastic leukemia and acute myeloid leukemia (AML) risk in males (additive model: aOR = 0.52; 95% CI: 0.29-0.95, p = 0.03; dominant model: aOR = 2.18; 95% CI: 1.17-4.05, p = 0.01, respectively).
|
25992585 |
2015 |
|
rs9282861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SULT1A1 (c.638G>A) was associated to infant acute lymphoblastic leukemia and acute myeloid leukemia (AML) risk in males (additive model: aOR = 0.52; 95% CI: 0.29-0.95, p = 0.03; dominant model: aOR = 2.18; 95% CI: 1.17-4.05, p = 0.01, respectively).
|
25992585 |
2015 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Infant ALL cases were more likely to harbor homozygous PON1 rs854560 alleles than controls (OR 1.72, 95 % CI 1.03-2.89); at least one M allele was associated with an increased risk of ALL in children older than 1 year (OR 1.99, 95 % CI 1.17-3.3).
|
22976839 |
2012 |
|
rs1131341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a variant of another allele at nt 465 (C465T, Arg139Trp), also associated with diminished enzyme activity, was strongly associated (OR 6.36; CI 1.84-21.90; p=0.002) with infant ALL, especially in t(4;11)(q21;q23), MLL-AF4.
|
16266898 |
2005 |
|
rs1258159645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies in Caucasian populations have provided evidence that a loss of function allele at nt 609 (C609T, Pro187Ser) is associated with increased risk of infant acute lymphoblastic leukemia (ALL) with MLL-AF4 fusion genes.
|
16266898 |
2005 |
|
rs1800566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies in Caucasian populations have provided evidence that a loss of function allele at nt 609 (C609T, Pro187Ser) is associated with increased risk of infant acute lymphoblastic leukemia (ALL) with MLL-AF4 fusion genes.
|
16266898 |
2005 |
|
rs587781288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The only mutation was a TGC-->TTC transversion (cys-->phe) at codon 141 in exon 5 in a case of infant ALL at relapse that occurred by subclone evolution after MLL gene translocation.
|
9546437 |
1998 |