NAT2, N-acetyltransferase 2, 10

N. diseases: 311; N. variants: 10
Disease: Rectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 GeneticVariation disease BEFREE Alcohol consumption associated with the NAT2 -T341C, G590A, G857A, A845C, and C481T rapid acetylator allele induces a risk of 10.63 (P<.001), 12.04 (P<.001), 9.76 (P<.001), 10.25 (P<.001), and 9.54 (P<.001), respectively, for colon cancer, whereas the risk for rectal cancer is 9.72 (P<.001), 11.24 (P<.001), 13.07 (P<.001), 10.04 (P<.001), and 9.43 (P<.001), respectively. 27883249 2017
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 GeneticVariation disease BEFREE N-Acetyltransferase 2 (NAT2) and glutathione S-transferase M1 (GSTM1) genotypes were investigated in 108 colon cancer cases, 80 rectum cancer cases, and 188 controls (suffering from nonmalignant diseases). 22686318 2012
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 Biomarker disease BEFREE NAT2-imputed phenotype and GSTM1 did not consistently modify rectal cancer risk associated with meat intake. 15051825 2004
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 GeneticVariation disease BEFREE Neither GSTM-1 genotype nor NAT2-imputed phenotype was independently associated with rectal cancer. 14504199 2003
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 Biomarker disease BEFREE Our study points to smoking as a risk factor for colon and rectal cancer and, in addition, especially in women with rapid NAT2 imputed phenotype. 12814209 2003
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.060 Biomarker disease BEFREE We conducted a population-based case-control study in Hawaii to test the associations of preference for well-done red meat and HAA intake with colon and rectal cancers, as well as the modifying effects of NAT2 and CYP1A2. 12351160 2002