MEF2B, myocyte enhancer factor 2B, 100271849

N. diseases: 42; N. variants: 4
Disease: Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.020 Biomarker group BEFREE MEF2B was positive in all FL and Burkitt lymphomas, 8/9 mantle cell lymphomas, 2/24 splenic MZL, 1/10 chronic lymphocytic leukemia/small lymphocytic lymphomas, and 38/44 diffuse large B-cell lymphoma (DLBCL), but was negative in all extranodal MZL of mucosa-associated lymphoid tissue, nodal MZL, and B-lymphoblastic lymphomas. 29309299 2018
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.020 GeneticVariation group BEFREE Mef2b<sup>D83V</sup> expression in mice leads to GC enlargement and lymphoma development, a phenotype that becomes fully penetrant in combination with BCL2 de-regulation, an event associated with human MEF2B mutations. 30205047 2018