Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, we found overexpression of miR-1231 suppressed proliferation, migration, and invasion of prostate cancer cell linesin vitro.EGFR was a direct target of miR-1231.
|
31822000 |
2020 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Rescue experiments revealed that circ-DCAF6 facilitated cell growth and invasion via suppressing the levels of miR-1231 and miR-1256.
|
31226266 |
2019 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304.
|
30709584 |
2019 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Taken together, our results indicate that miR-1231 expression plays a tumor-suppressive role in prostate cancer.
|
31822000 |
2020 |
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The exosomal miR-1231 of peripheral blood may also be a potential indicator for PC diagnosis in the future.
|
31642612 |
2019 |
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
The exosomal miR-1231 of peripheral blood may also be a potential indicator for PC diagnosis in the future.
|
31642612 |
2019 |
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the downregulation of miR-1231 negatively correlated with the clinical stage of human glioma patients. miR-1231 overexpression dramatically downregulated glioma cell proliferation, and suppressed tumor growth in a nude mouse model.
|
29774498 |
2018 |
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We determined the expression level of miR-1231 in 154 cases of paired glioma and adjacent non-tumor tissues by quantitative Real Time-PCR (qRT-PCR).
|
30556881 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma.
|
29774498 |
2018 |
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
Serum also contains microRNAs, a class of small non-coding RNAs that play an important role in regulating gene expression. miR-122 is specific to the liver and correlates strongly with liver enzyme levels and necroinflammatory activity, and other microRNAs are correlated with the degree of fibrosis. miR-122 has also been found to be required for hepatitis C virus (HCV) infection, whereas other microRNAs have been shown to play antiviral roles. miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV) transcripts, and others are up- or down-regulated in infected individuals.
|
26927063 |
2016 |
Pancreatic carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation.
|
27213290 |
2016 |
Malignant neoplasm of pancreas
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation.
|
27213290 |
2016 |
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Four miRNAs, hsa-miR-486-3p, hsa-miR-1908, hsa-miR-675 and hsa-miR-1231 were upregulated in mouse and human livers with HBV infection.
|
24835118 |
2014 |
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that miR-1231 expression plays a tumor-suppressive role in prostate cancer.
|
31822000 |
2020 |
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results indicate that miR-1231 expression plays a tumor-suppressive role in prostate cancer.
|
31822000 |
2020 |
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of miR-1231 was significantly associated with lymph node metastasis, higher TNM stage, higher clinical stage, and shorter overall survival.
|
31822000 |
2020 |
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR‑1231 pathway in bladder cancer progression.
|
31545480 |
2019 |
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR‑1231 pathway in bladder cancer progression.
|
31545480 |
2019 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The exosomes extracted from BM-MSCs with high level of miR-1231 inhibit the activity of PC, providing the potential application for developing new and efficient medicine for cancer therapy, especially for PC treatment.
|
31642612 |
2019 |
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR‑1231 pathway in bladder cancer progression.
|
31545480 |
2019 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The exosomes extracted from BM-MSCs with high level of miR-1231 inhibit the activity of PC, providing the potential application for developing new and efficient medicine for cancer therapy, especially for PC treatment.
|
31642612 |
2019 |
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the miR-1231/EGFR axis may be a helpful future diagnostic target for malignant glioma.
|
29774498 |
2018 |
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, the inhibition of miR-1231 <i>in vivo</i> ameliorates arrhythmias in rat MI hearts; conversely, the forced overexpression of miR-1231 promotes arrhythmias.
|
28469787 |
2017 |
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-1231 exacerbates arrhythmia by targeting calciumchannel gene <i>CACNA2D2</i> in myocardial infarction.
|
28469787 |
2017 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum also contains microRNAs, a class of small non-coding RNAs that play an important role in regulating gene expression. miR-122 is specific to the liver and correlates strongly with liver enzyme levels and necroinflammatory activity, and other microRNAs are correlated with the degree of fibrosis. miR-122 has also been found to be required for hepatitis C virus (HCV) infection, whereas other microRNAs have been shown to play antiviral roles. miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV) transcripts, and others are up- or down-regulated in infected individuals.
|
26927063 |
2016 |