SH2D3C, SH2 domain containing 3C, 10044

N. diseases: 21; N. variants: 2
Disease: Chikungunya Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Here, we identify the DExH-box RNA helicase 9 (DHX9) as a binding partner of chikungunya virus (CHIKV) nsP3 mainly interacting with the C-terminal hypervariable domain. 30463980 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Expression, purification and functional characterization of recombinant hypervariable region (HVR) of Chikungunya virus nsP3 protein. 31139550 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Overall, this study shows that FHL1 is a key factor expressed by the host that enables CHIKV infection and identifies the interaction between nsP3 and FHL1 as a promising target for the development of anti-CHIKV therapies. 31554973 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein. 31493651 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Development of a theoretical model for the inhibition of nsP3 protease of Chikungunya virus using pyranooxazoles. 31366291 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes. 30412583 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.070 Biomarker disease BEFREE We developed positive- and negative-strand qRT-PCR assays to detect nsP3 of chikungunya virus (CHIKV), a positive-strand RNA alphavirus that causes epidemic fever, rash, and arthritis. 23886793 2013