|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that dietary calcium suppresses oral carcinogenesis, but the mechanism is unclear. p120-catenin (p120) is a cytoplasmic protein closely associated with E-cadherin to form the E-cadherin-β-catenin complex and may function as a tumor suppressor in the oral epithelium.
|
27682597 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.
|
29130932 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice with biallelic loss of p120 catenin progressively develop high-grade pancreatic intraepithelial neoplasia (PanIN) lesions and neoplasia accompanied by prominent acute and chronic inflammatory processes, which is mediated, in part, through NF-κB signaling.
|
27032419 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis.
|
25713299 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunohistochemical expression of α-, β- and p120-catenin was studied in a series of normal feline mammary glands, hyperplastic/dysplastic lesions and benign and malignant mammary tumors.
|
26026096 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CAS/imp-α1 transport cycle is linked to XIAP and is required to maintain tumor cell survival in HCC.
|
24799195 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene.
|
21481789 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We detected changes in 'boundary cells' within histological sections of human squamous cell carcinomas that were similar to those observed in Drosophila: both E-cadherin and p120-catenin exhibited normal junctional localization at the centers of the tumors but were reduced or delocalized at the boundary.
|
20363916 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors.
|
20470445 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, reduced expression of P120 catenin mRNA and protein in tumour correlated with a worse prognosis and normal expression with a better survival rate (P=0.022, P=0.007).
|
19754472 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accumulating evidences indicate that p120-catenin is important in tumour formation and progression, although the role of their multiple spliced isoforms in the regulation of cadherin-mediated adhesion of malignant cells is still not well understood.
|
18032823 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors.
|
9472046 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For image analysis, Feulgen-stained slides of tumor imprints and of disaggregated tumor cytospin preparations were evaluated with the CAS-200 image analyzer.
|
2047381 |
1991 |