|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell-specific moloney leukemia virus insertion site 1 (Bmi-1) plays important roles in various cancers, but its regulation through microRNAs (miRNAs) and its functions in hepatocellular carcinoma (HCC) remains unclear.
|
29906128 |
2018 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) is a crucial regulator of CSC self-renewal, malignant transformation and EMT, and a previous study from our group showed that Bmi-1 is upregulated in pancreatic cancer progression and participates in EMT.
|
30453285 |
2018 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the prognosis of pediatric patients with acute lymphoblastic leukemia (ALL) has not been well studied.
|
28122538 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) is required for the self-renewal and maintenance of AML stem cells.
|
28211885 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, quantitative real-time polymerase chain reaction was used to study changes in the expression of tumor suppressor proteins 53 and 21 ( P53 and P21), cluster of differentiation 44 ( CD44), and B cell-specific Moloney murine leukemia virus integration site 1 ( BMI-1) upon treatments.
|
27207438 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The oncoprotein B-cell-specific Moloney murine leukemia virus integration site 1 protein (Bmi-1) has been linked to the development and progression of glioma; however, the biological role of Bmi-1 in the invasion of glioma remains unclear.
|
22967049 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also observed that HOXA9 levels were significantly inversely correlated with survival and that BMI-1 was overexpressed in cases with 11q23 rearrangements, suggesting that p19(ARF) suppression may be involved in MLL-associated leukemia.
|
18668134 |
2008 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examine the role of Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) as a regulator of human epidermal keratinocyte survival.
|
17625597 |
2008 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of the best candidate genes involved in conferring self-renewal capacity is Bmi-1, which has been proven to be essential for the maintenance of both normal adult hematopoietic and leukemia stem cells, as well as adult neural stem cells.
|
17395774 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It has been demonstrated that over-expression of Bmi-1 occurs in a variety of cancers, including several types of leukemia.
|
17454639 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reducing SALL4 expression by siRNA in the HL-60 leukemia cell line also results in significant down-regulation of Bmi-1.
|
17557835 |
2007 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) on metaphase chromosome spreads located the human BMI-1 gene to the short arm of chromosome 10 (10p13), a region known to be involved in translocations in various leukemias.
|
8268912 |
1993 |