Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, PIAS, SOCS, and PTP have also been reported to correlate with tumor malignancy, and their biological function in tumorigenesis and antitumor therapy are somewhat controversial.
|
31213912 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we report that PTPRU serves as a tumor suppressor that inhibits cancer stemness by attenuating Hippo/YAP signaling pathway.
|
31632062 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have unveiled both oncogenic and tumor suppressive functions of PTP in HCC.
|
29558404 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results show that ROS-induced oxidation of PTPN12 accounts for ABL1 phosphorylation in HLRCC-associated PRCC, revealing a novel mechanism for inactivating a tumor suppressor gene product and establishing a direct link between pathologic PTP oxidation and neoplastic disease.
|
30297534 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor growth was suppressed in mice following two week's PTP administration (10, 20 and 40mg/kg) due to the induction of apoptosis, as detected by TUNEL assay.
|
28923567 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Protein tyrosine phosphatase receptor‑type O (PTPRO), a member of the PTP family, has been frequently reported as potential tumor suppressor in many types of cancer.
|
28586036 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we set out to characterize the role of PTPRU in glioma and found that, while the expression of full-length PTPRU protein is low in these tumors, a number of non-full-length PTPRU isoforms are highly expressed.
|
24876153 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transmembrane protein-tyrosine phosphatase (PTP) DEP-1 (density-enhanced phosphatase) is a candidate tumor suppressor in the colon epithelium.
|
16682945 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PTPROt is a member of the PTPRO family (also designated GLEPP, PTP-Ø, PTP-oc, and PTPu2), a group of highly conserved receptor-type PTPs that are thought to function as tumor suppressor genes.
|
16888096 |
2006 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of normal PTP-S4 in PyF cells significantly increased anchorage-independent cell growth and tumor formation in nude mice.
|
11597125 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results are the first to suggest that PTP gamma is a potential estrogen-regulated tumor suppressor gene in human breast cancer which may play an important role in neoplastic processes of human breast epithelium.
|
10769629 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, the genomic structure, position of the proximal promotor, and intron-exon border sequences of the 30-exon 780-kb PTP gamma gene have been determined, which will facilitate analysis of the PTP gamma gene in tumors.
|
8833149 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The protein tyrosine phosphatase gamma (PTP gamma) gene has recently been suggested as a candidate tumor suppressor gene involved in the oncogenesis of human lung and renal cancers, although no direct evidence for PTP gamma mutations has been demonstrated thus far.
|
1596910 |
1992 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the PTP gamma gene has characteristics that suggest it as a candidate tumor suppressor gene at 3p21.
|
1711217 |
1991 |