Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
KCNQ1OT1 aggravates AML progression and chemoresistance to ADR by inducing Tspan3 expression via adsorbing miR-193a-3p in ADR resistant AML cells, providing a theoretical basis for the treatment of AML with chemoresistance.
|
31837329 |
2020 |
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that a significant reduction in miR-139-5p expression and a prominent increase in Tspan3 expression were observed in AML patients and cells.
|
30367526 |
2019 |
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche.
|
26212080 |
2015 |
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tetraspanin 3 (Tspan3), which is highly expressed in the murine brain and elevated in brains of Alzheimer´s disease (AD) patients, was identified and confirmed to bind ADAM10 by co-immunoprecipitation experiments in mammalian cells in complex with APP and the γ-secretase protease presenilin.
|
27818272 |
2017 |
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
After its downregulation in neuroblastoma cells and in brains of Tspan3-deficient mice, ADAM10 and APP levels appeared unaltered possibly due to a compensatory increase in the expression of Tspans 5 and 7, respectively.
|
27818272 |
2017 |
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
After its downregulation in neuroblastoma cells and in brains of Tspan3-deficient mice, ADAM10 and APP levels appeared unaltered possibly due to a compensatory increase in the expression of Tspans 5 and 7, respectively.
|
27818272 |
2017 |
Alzheimer disease, familial, type 3
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tetraspanin 3 (Tspan3), which is highly expressed in the murine brain and elevated in brains of Alzheimer´s disease (AD) patients, was identified and confirmed to bind ADAM10 by co-immunoprecipitation experiments in mammalian cells in complex with APP and the γ-secretase protease presenilin.
|
27818272 |
2017 |
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
After its downregulation in neuroblastoma cells and in brains of Tspan3-deficient mice, ADAM10 and APP levels appeared unaltered possibly due to a compensatory increase in the expression of Tspans 5 and 7, respectively.
|
27818272 |
2017 |
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
|
26212080 |
2015 |
Acute Undifferentiated Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML.
|
26212080 |
2015 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
|
26212080 |
2015 |
Undifferentiated leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML.
|
26212080 |
2015 |