ADAM8, ADAM metallopeptidase domain 8, 101

N. diseases: 81; N. variants: 2
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE Although some studies have described the function of ADAM8 (a disintegrin and metalloprotease 8) related with rheumatoid arthritis, cancer and asthma, etc., the concrete role of ADAM8 in acute liver injury is still unknown. 24646716 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.040 AlteredExpression disease BEFREE ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. 24147597 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE This review outlines the current contradictory concepts concerning the role of ADAM8 in airway inflammation, particularly focusing on the recruitment of leukocytes during asthma, and attempts to bridge the existing experimental data on the basis of the functional analysis of different domains of ADAM8 and their endogenous processing in vivo. 23837412 2013
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma. 17339047 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease LHGDN ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma. 17339047 2007