ADAM8, ADAM metallopeptidase domain 8, 101

N. diseases: 81; N. variants: 2
Disease: CNS disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.010 Biomarker group BEFREE Our results indicate an essential role for ADAM8 in modulating TNF-alpha signaling in CNS diseases: a feedback loop integrating TNF-alpha, ADAM8, and TNF-R1 shedding as a plausible mechanism for TNF-alpha mediated neuroprotection in situ and a rationale for therapeutic intervention. 20826683 2010