|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
This review highlights the remarkable effects of ADAM8 in tumor biology, concluding that pharmacological inhibition of ADAM8 represents a promising therapeutic approach not only for monotherapy, but also for combinatorial therapies.
|
30635388 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The 5-year DFS in colon cancer, T3-T4 stage, N0 stage, TNM stage II, adenocarcinoma, moderate differentiation and male patient subgroups was also worse for patients with ADAM8-positive tumors than those with ADAM8-negative tumors (p < 0.05).
|
25098630 |
2014 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Protein expression level of ADAM8 was markedly higher in HCC tissues than that in the normal liver tissues (P = 0.0058).In addition,high expression of ADAM8 protein was positively correlated with serum AFP elevation,tumor size,histological differentiation,tumor recurrence,tumor metastasis,and tumor stage.
|
22965687 |
2013 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Expression of ADAM8 and ADAM15 correlated significantly with tumour stage (P=0.048 and P=0.044), and ADAM12 expression correlated with tumour grade (P=0.011).
|
22677901 |
2012 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
According to the immunohistochemisty analysis, we found statistically significant correlations of high ADAM8 protein expression with advanced metastatic stage (P=0.01), aggressive histopathological type (P=0.006), as well as with undifferentiated tumor (P=0.02).
|
22959284 |
2012 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
ADAM8 and its Delta14' isoform expression levels were markedly increased in lung cancer cells, in conditions mimicking tumor microenvironment.
|
20453887 |
2010 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
The ADAM8 and ADAM19 proteins were mainly located in tumor cells and in some tumors in endothelia of blood vessels.
|
16772875 |
2006 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We investigated the mRNA expression of ADAM-8, -17, -19, -28, ADAM-TS1, and ADAM-TS2 in paired tissue samples from cancerous and non-cancerous parts of the kidneys of 27 patients with RCC who underwent tumour nephrectomy.
|
14719095 |
2004 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Tumor tissue microarray was applied to examine expression of ADAM8 protein in archival lung cancer samples from 363 patients.
|
15623614 |
2004 |