ADAM8, ADAM metallopeptidase domain 8, 101

N. diseases: 81; N. variants: 2
Disease: Secondary Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 Biomarker group BEFREE ADAM8 is reported to promote extracellular matrix degradation to provide conditions for tumor metastasis. 31305294 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 Biomarker group BEFREE To investigate the function of ADAM8 in metastasis, MB-231 breast cancer cells with ADAM8 knockdown (MB-231_shA8) and scramble control cells (MB-231_shCtrl) were analyzed for their capability to develop metastases. 28986926 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 AlteredExpression group BEFREE The transmembrane ADAM8 (A Disintegrin And Metalloproteinase 8) protein is abundantly expressed in human breast tumors and derived metastases compared with normal breast tissue, and plays critical roles in aggressive Triple-Negative breast cancers (TNBCs). 25336660 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.040 AlteredExpression group BEFREE The expression of ADAM-8 was related to a shorter survival of patients and was the best predictor of distant metastases. 14719095 2004