Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IFNL4 genotype has also been linked to variation within the HCV genome, as well as risk of hepatic fibrosis, certain cancers and some infectious disease.
|
31846709 |
2020 |
Hepatitis C
|
0.200 |
Biomarker
|
disease |
BEFREE |
Changes in LDL among CHC patients who achieved SVR differed by IFNL4 genotype, which implicates the interferon-λ4 protein in metabolic changes observed in HCV-infected patients.
|
31504644 |
2020 |
Hepatitis C
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interferon lambda 4 (IFNλ4) has been recently known and studied for its role in hepatitis C virus (HCV) infection, but its clinical potential is significantly hampered due to its poor expression in vitro.
|
31479875 |
2020 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Compared to patients without OCI, unfavorable IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ∆G/∆G genotypes were more frequently reported in OCI patients.
|
31838260 |
2020 |
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated longitudinal changes in metabolic and inflammatory outcomes in chronic hepatitis C (CHC) patients: low-density lipoprotein (LDL), high-density lipoprotein, triglycerides, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) using a general linear model for repeated measurements at 5 clinical time points and by human immunodeficiency virus (HIV) coinfection and IFNL4 genotype.
|
31504644 |
2020 |
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The finding that a "knock-out" allele for IFN-λ4 enhances HCV clearance challenges the paradigm of IFNs as antiviral cytokines.
|
31161939 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants within the <i>IFNL</i> region, including those controlling production and activity of IFN-λ4, have been strongly associated with clearance of hepatitis C virus (HCV) infection.
|
31070498 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We show that genetic variants within the IFN lambda 4 (<i>IFNL4</i>) locus are the major factors associated with the studied traits, accordingly with observations in other HCV genotypes and with comparable effect sizes.
|
31260374 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Strong linkage disequilibrium of IFNL4 rs12979860 with IFNL4 rs368234815, which is casually associated with HCV spontaneous and therapeutical eradication, at least partially explains favorable HCV outcomes attributed to major homozygosity in rs12979860.
|
30027841 |
2019 |
Hepatitis C
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although the ability to produce IFN-λ4 is associated with decreased HCV clearance, the recombinant IFN-λ4 is active against HCV and other viruses.
|
31241411 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection.
|
30289470 |
2019 |
Hepatitis C
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we examined the role played by interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays a crucial role in spontaneous clearance or establishment of chronicity following acute infection.
|
31478835 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the meta-analysis, significant associations with HCV clearance were confirmed at the interferon lambda gene locus IFNL4-IFNL3 (19q13.2) (P = 5.99 × 10<sup>-50</sup>) and the MHC locus 6p21.32 (P = 1.15 × 10<sup>-21</sup>).
|
30593799 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI.
|
30821879 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Impact of IFNL4 Genetic Variants on Sustained Virologic Response and Viremia in Hepatitis C Virus Genotype 3 Patients.
|
31260374 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.
|
30593799 |
2019 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The relationship between IFNL4 genotype and the rate of fibrosis in hepatitis C patients.
|
31479286 |
2019 |
Hepatitis C
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Comparison of published gene expression data from humans and chimpanzees showed that this difference in activity between K154 and E154 in IFNλ4 correlates with differences in antiviral gene expression in vivo during HCV infection.
|
30308076 |
2018 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The recently described rs368234815 TT/ΔG dinucleotide and rs117648444 nonsynonymous rs117648444" genes_norm="101180976;282617">P70S polymorphisms in IFN lambda 4 (IFNL4) gene, which are strongly associated with response to IFN in hepatitis C virus (HCV) infection, could be also useful in IFN-treated CHB patients.
|
28732143 |
2018 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Impact of IFNL4-∆G genotype on sustained virologic response in hepatitis C genotype 1 patients treated with direct-acting antivirals.
|
29866411 |
2018 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In chronic hepatitis C virus (HCV) infections, where the IFNL variants were first identified to be associated with response to interferon-α-ribavirin therapy, the available data clearly suggests that the causal variant could be the dinucleotide polymorphism rs368234815 that causes an open reading frame-shift in the IFNL4 gene resulting in expression of a functional IFN-λ4, a new type III IFN.
|
29705128 |
2018 |
Hepatitis C
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection.
|
29165633 |
2018 |
Hepatitis C
|
0.200 |
Biomarker
|
disease |
BEFREE |
Impact of Interferon Lambda 4 Genotype on Interferon-Stimulated Gene Expression During Direct-Acting Antiviral Therapy for Hepatitis C.
|
29534310 |
2018 |
Hepatitis C
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In summary, intrahepatic expression of IFNL4 was associated with increased antiviral ISG expression and decreased suppressive ISG expression at baseline, resulting in poor responsiveness to IFNα-based therapy in HCV infection.
|
28036111 |
2017 |