TRAP1, TNF receptor associated protein 1, 10131

N. diseases: 90; N. variants: 18
Disease: Prostatic Intraepithelial Neoplasias ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282612
Disease: Prostatic Intraepithelial Neoplasias
Prostatic Intraepithelial Neoplasias 		0.010 GeneticVariation disease BEFREE When examined on a Pten<sup>+/-</sup> background, a common alteration in human prostate cancer, TRAP1 transgenic mice showed accelerated incidence of invasive prostatic adenocarcinoma, characterized by increased cell proliferation and reduced apoptosis, in situ Conversely, homozygous deletion of TRAP1 delays prostatic tumorigenesis in Pten<sup>+/-</sup> mice without affecting hyperplasia or prostatic intraepithelial neoplasia. 27754870 2016