|
Colorectal Carcinoma
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
An analysis of genes possibly regulated by miR-181a-2* was carried out and, amongst these, an inverse correlation of NAMPT with miR-181a-2* expression was observed, whereas, for TRAF1 and SALL1, additional regulation mechanisms involving CpG island methylation were observed. miR-181a-2* is associated with particular histological and molecular features of colorectal carcinomas within the serrated pathological pathway and might play a role in the immune responses of microsatellite instability carcinomas.
|
31784758 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
In this study, we showed that NAMPT protein expression was increased in subjects with rectal localization compared with those with colon localization, and NAMPT was a poor prognostic marker for the overall survival rate in patients with CRC.
|
30191976 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results suggest that NAMPT-mediated upregulation of the NAD(H) pool protects cancer cells against detrimental oxidative stress and that detecting NADH fluorescence by TPEF microscopy could be a potential method for monitoring CRC progression.
|
30457689 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
Biomarker
|
disease |
BEFREE |
We investigated the resistance mechanisms of NAMPT inhibitor FK866 in human colorectal cancer (CRC) cells.
|
31810909 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
Biomarker
|
disease |
BEFREE |
Assessing functional and molecular consequences of pharmacological interference with factors of the loop, we found that inhibition of NAMPT resulted in apoptosis and reduced clonogenic growth in human BRAF-mutant colorectal cancer cell lines and patient-derived tumoroids.
|
31442917 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
High expression of NAMPT or NAPRT predicts short overall survival and disease-free survival time in CRC patients, which were further confirmed by public datasets.
|
31448236 |
2019 |
|
Colorectal Carcinoma
|
0.570 |
Biomarker
|
disease |
BEFREE |
Targeting of NAMPT or SIRT1 may represent novel therapeutic strategies with putative higher sensitivity of the serrated route colorectal cancer subtype.
|
30460421 |
2018 |
|
Colorectal Carcinoma
|
0.570 |
Biomarker
|
disease |
CTD_human |
Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells.
|
23922874 |
2013 |
|
Colorectal Carcinoma
|
0.570 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT.
|
31533725 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
NAMPT-mediated NAD<sup>+</sup> biosynthesis is indispensable for adipose tissue plasticity and development of obesity.
|
29551635 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis.
|
28333140 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate if genetic variations in the visfatin gene (SNPs rs7789066/ rs11977021/rs4730153) could modify the cardiovascular-risk (CV-risk) despite the metabolic phenotype (obesity and glucose tolerance).
|
27166797 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association of Pre-B cell colony enhancing factor 1 (PBEF1) with obesity, together with its pro-inflammatory properties suggests that PBEF1 might be another crucial mediator that links inflammation with obesity and primary osteoarthritis (OA).
|
26752339 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this Review, we discuss current understanding of the functions of NAMPT and highlight progress made in identifying the physiological role of NAMPT and its relevance in various human diseases and conditions, such as obesity, NAFLD, T2DM, cancer and ageing.
|
26215259 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the NAMPT gene, which encodes the adipocytokine visfatin/nicotinamide phosphorybosil transferase (NAMPT), affect the circulating visfatin/NAMPT levels and are associated with obesity and cardiovascular diseases.
|
24100423 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatic overexpression of miR-34a reduced NAMPT/NAD(+) levels, increased acetylation of the SIRT1 target transcriptional regulators, PGC-1α, SREBP-1c, FXR, and NF-κB, and resulted in obesity-mimetic outcomes.
|
23834033 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results demonstrate the association of the common variants of IL6, LEPR, and PBEF1 with obesity in Indian children.
|
22228719 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes.
|
21687707 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NAMPT circulating concentrations (P<0.01) and gene expression levels in PBC (P<0.05) were significantly increased in obese patients as compared to lean subjects.
|
20106640 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leucocytes are a major source of enzymatically active NAMPT, which may serve as a biomarker or even mediator linking obesity, inflammation and insulin resistance.
|
21298414 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A cross-sectional analysis of human subjects showed that athletes had about a twofold higher skeletal muscle NAMPT protein expression compared with sedentary obese, nonobese, and type 2 diabetic subjects (P < 0.05).
|
19887595 |
2010 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, visfatin/PBEF/Nampt expression was significantly upregulated in obese type 2 diabetic patients, whereas obese nondiabetics exhibited similar levels compared to lean controls, indicating that visfatin/PBEF/Nampt levels are related to type 2 diabetes rather than to obesity.
|
20091460 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed at investigation of the possibility that single-nucleotide polymorphisms (SNPs) in the visfatin gene are associated with either obesity or type 2 diabetes (T2D).
|
19300429 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |