|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.
|
31015462 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
|
30604766 |
2019 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xenograft MM model.
|
31213901 |
2019 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In ARP-1 and MM.1S tumor-bearing mice, repeat STRO-001 dosing provided significant antitumor activity with eradication of malignant hCD138+ BM plasma cells and prolonged survival.
|
30701025 |
2018 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We applied ND and MM-MSCs 72h secretomes to MM cell lines (U266 and ARP-1) for 12-72h and then assayed the cells' (viability, cell count, cell death, proliferation, cell cycle, autophagy) and TI (factors: eIF4E, teIF4GI; regulators: mTOR, MNK1/2, 4EBP; targets: cyclin D1, NFκB, SMAD5, cMyc, HIF1α).
|
26976208 |
2016 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Forced expression of bcl-2 in 8226 and ARP-1 multiple myeloma (MM) cell lines expressing relatively low levels of bcl-2, resulted in 1-2 log increase in resistance to dexamethasone (DEX)-induced apoptosis.
|
9454907 |
1998 |
|
Syphilis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From September 2009 to August 2013, we collected 658 clinical specimens from 375 patients who presented with syphilis for genotyping to examine the number of 60-bp repeats in the acidic repeat protein (arp) gene, T. pallidum repeat (tpr) polymorphism, and tp0548 gene, and to detect A2058G and A2059G point mutations by restriction fragment length polymorphism.
|
24438059 |
2014 |
|
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections.
|
23925294 |
2013 |
|
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rotavirus was able to neutralise rotavirus infection in a mouse model system.
|
22403728 |
2012 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis.
|
18554302 |
2008 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Idiopathic chronic pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathogenic genetic variants were identified in 58, 63, and 27% of patients with ARIP, an unexplained first episode of AP <35 years of age, and ICP without ARP, respectively.
|
28440306 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay.
|
28454546 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Orally administered MucoRice-ARP1 markedly decreased the viral load in immunocompetent and immunodeficient mice.
|
23925294 |
2013 |
|
Spinocerebellar Ataxia Type 5
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.
|
20603325 |
2010 |
|
Pancreatic carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).
|
17072959 |
2006 |
|
Malignant neoplasm of pancreas
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).
|
17072959 |
2006 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Esophageal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, they were also found in its corresponding normal tissues, suggesting that variation of the ARP gene found in ESC is polymorphic.
|
10767373 |
2000 |
|
Malignant neoplasm of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene.
|
9539779 |
1998 |
|
Choriocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Co-transfection of an ARP-1 expression vector into BeWo choriocarcinoma cells, along with an expression vector containing 1.2 kb of the hPL promoter coupled to a CAT reporter gene, resulted in a dose-dependent inhibition of basal CAT activity.
|
8782080 |
1996 |