CDK5, cyclin dependent kinase 5, 1020

N. diseases: 204; N. variants: 3
Disease: Tauopathies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.320 GeneticVariation group BEFREE To further validate the role of p25/Cdk5 in tauopathy, we used frontotemporal dementia patient-derived induced pluripotent stem cells (iPSCs) carrying the Tau P301L mutation and generated P301L:Δp35KI isogenic iPSC lines using CRISPR/Cas9 genome editing. 28912154 2017
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.320 Biomarker group CTD_human Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice. 26945731 2016
CUI: C0949664
Disease: Tauopathies
Tauopathies 		0.320 PosttranslationalModification group BEFREE Given the contribution of both CDK5/p25 and GSK3β to Tau phosphorylation, effective treatment of tauopathies may require dual kinase targeting. 23737518 2013