|
Tonometry
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses identify new loci influencing intraocular pressure.
|
29617998 |
2018 |
|
Glaucoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
ANGPTL7 is a newly-discovered member of the ANGPTL family and plays a role in corneal morphogenesis, angiogenesis, glaucoma, and cancer.
|
31835268 |
2019 |
|
Glaucoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The biological role of ANGPTL7 is yet to be understood except for a recently proposed role in the pathophysiology of glaucoma.
|
28264047 |
2017 |
|
Glaucoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Together with previous findings, these properties strengthen ANGPTL7's candidacy for the regulation of IOP and glaucoma.
|
21199193 |
2011 |
|
Glaucoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
The concentration of ANGPTL7 protein in aqueous humor (AH) from patients with glaucoma and control patients was compared by Western blot analysis.
|
18421092 |
2008 |
|
Glaucoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The concentration of ANGPTL7 protein in aqueous humor (AH) from patients with glaucoma and control patients was compared by Western blot analysis.
|
18421092 |
2008 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
ANGPTL7 is a newly-discovered member of the ANGPTL family and plays a role in corneal morphogenesis, angiogenesis, glaucoma, and cancer.
|
31835268 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
ANGPTL7 is a newly-discovered member of the ANGPTL family and plays a role in corneal morphogenesis, angiogenesis, glaucoma, and cancer.
|
31835268 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
It is unknown if CDT6 expression occurs in human cancer.
|
17695521 |
2007 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To address the controversial role of CDT6 on angiogenesis in different tumour models, the expression levels of four factors of the angiogenic balance (VEGF, endostatin, TIMP-1 and PAI-1) were determined in CDT6-transfected and control cells of the human and murine melanoma cell lines BLM and B16-F10.
|
17695521 |
2007 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
None of 18 cell lines or 23 tumours expressed CDT6.
|
17695521 |
2007 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
It is unknown if CDT6 expression occurs in human cancer.
|
17695521 |
2007 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this report we describe the generation of a stably CDT6-expressing clone of the murine melanoma cell line B16-F10.
|
12792978 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Effects of the CDT6/ANGX gene on tumour growth in immune competent mice.
|
12792978 |
2004 |
|
Hypertensive disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ANGPTL7 was highly expressed in patients with hypertension.
|
31302653 |
2019 |
|
Osteoporosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, to discover the effects of ANGPTL7 on osteoporosis, we explored the expression of ANGPTL7 in preosteoblasts and assessed the mechanism underlying its effects on proliferation and differentiation abilities of preosteoblasts.
|
31835268 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was designed to shed light on the function of ANGPTL7 in obesity and its modulation by physical exercise as well as its potential association with lipid profile.
|
28264047 |
2017 |
|
Dyslipidemias
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Physical exercise reduced the level of ANGPTL7 highlighting the potential for targeting this protein as a therapeutic target for regulating dyslipidemia.
|
28264047 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, analysis of The Cancer Genome Atlas colorectal and breast cancer data sets revealed striking ANGPTL7 underexpression in cancerous compared to normal tissues.
|
25854806 |
2015 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Expression of ANGPTL7 (angiopoietin-like 7), a protein not previously linked to metastasis, was highly up-regulated in cancer cells after myeloid cell depletion.
|
25854806 |
2015 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This effect was duplicated in tissue culture, where coculture of cancer cells with tumor-conditioned myeloid cells from liver metastases or myeloid cell conditioned media down-regulated ANGPTL7 expression.
|
25854806 |
2015 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, analysis of The Cancer Genome Atlas colorectal and breast cancer data sets revealed striking ANGPTL7 underexpression in cancerous compared to normal tissues.
|
25854806 |
2015 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of these, five loci showed highest methylation levels in HCC and lowest in control tissue (LOC55908, CELSR1, CRMP1, GNRH2, ALOX12 and ANGPTL7), whereas two loci showed the opposite direction of change (SPRR3 and TNFSF15).
|
21500188 |
2012 |
|
Intraocular pressure disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together with previous findings, these properties strengthen ANGPTL7's candidacy for the regulation of IOP and glaucoma.
|
21199193 |
2011 |
|
Glaucoma, Primary Open Angle
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The beagle model of primary open-angle glaucoma (POAG) was used to correlate ANGPTL7 protein levels in canine AH with disease progression.
|
18421092 |
2008 |